SEX-DIFFERENCES IN COLONIC FUNCTION - A RANDOMIZED TRIAL
SEX-DIFFERENCES IN COLONIC FUNCTION - A RANDOMIZED TRIAL
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DOI：
10.1136/gut.34.4.531
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发表时间：
1993-04-01
期刊：
影响因子：
24.5
通讯作者：
POTTER, JD
中科院分区：
文献类型：
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作者：
LAMPE, JW;FREDSTROM, SB;POTTER, JD
大肠癌和各种其他胃肠道疾病的发病率存在性别差异，这可能是因为肠道生物学的差异。为了确定男性和女性在摄入相同的膳食纤维时是否有不同的胃肠道反应，16名女性和18名男性食用液体配方饮食和含有0克、10克和30克纤维的“快速面包”，如麦麸和植物纤维。五种试验饮食以随机顺序消耗，每次处理持续23天。与女性相比，男性的平均通过时间更快（p=0.02），粪便重量（g/天）更大（p=0.0005）。中性洗涤纤维（NDF）排泄量在男性中更大（p=0.01），女性倾向于消化更多的NDF（p=0.06）。男性和女性似乎对麦麸和植物纤维在NDF排泄和消化率方面的反应不同。粪便pH值或含水量无性别差异。男性次级胆汁酸、石胆酸和脱氧胆酸的浓度和每日排泄量高于女性（p
There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid formula diets and 'quick breads' with 0 g, and 10 g, and 30 g of fibre as wheat bran and vegetable fibre. The five test diets were consumed in random order, each treatment lasting 23 days. Mean transit time was faster (p=0.02), and stool weights (g/day) were greater (p=0.0005) for men than women. Neutral detergent fibre (NDF) excretion was greater in men (p=0.01), and women tended to digest more NDF (p=0.06). Men and women seemed to respond differently to wheat bran and vegetable fibre with regard to NDF excretion and digestibility. There were no gender differences in the faecal pH or moisture content. Concentrations and daily excretion of the secondary bile acids, lithocholic and deoxycholic acid, were greater for men than women (p