Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses.
Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses.
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DOI：
10.1155/2012/512097
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发表时间：
2012
影响因子：
2
通讯作者：
Graeff-Teixeira C
中科院分区：
文献类型：
--
作者：
Morassutti AL;Graeff-Teixeira C
广州管圆线虫是一种引起人类嗜酸性脑膜脑炎的线虫寄生虫。疾病出现后，第三阶段的幼虫居住在中间软体动物宿主和疾病表现为急性炎症的脑膜特征为嗜酸性粒细胞浸润，释放一系列的促炎和细胞毒性剂，以响应病原体。作为中和这些宿主防御的机制，A.广州对虾表达具有免疫调节特性的不同分子，这些分子被排泄或分泌（ES）。在本文中，我们讨论了ES蛋白在疾病恶化中的作用及其作为治疗靶点的潜在用途。
Angiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningoencephalitis in humans. Disease presents following the ingestion of third-stage larvae residing in the intermediate mollusk host and disease manifests as an acute inflammation of the meninges characterized by eosinophil infiltrates which release a battery of proinflammatory and cytotoxic agents in response to the pathogen. As a mechanism of neutralizing these host defenses, A. cantonensis expresses different molecules with immunomodulatory properties that are excreted or secreted (ES). In this paper we discuss the role of ES proteins on disease exacerbation and their potential use as therapeutic targets.