Ultra-high resolution profiles of macular intra-retinal layer thicknesses and associations with visual field defects in primary open angle glaucoma.
Ultra-high resolution profiles of macular intra-retinal layer thicknesses and associations with visual field defects in primary open angle glaucoma.
复制标题
黄斑视网膜内层厚度的超高分辨率分布及其与原发性开角青光眼视野缺陷的关联
DOI：
10.1038/srep41100
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发表时间：
2017-02-07
影响因子：
4.6
通讯作者：
Shen M
中科院分区：
文献类型：
--
作者：
Chen Q;Huang S;Ma Q;Lin H;Pan M;Liu X;Lu F;Shen M
原发性开角型青光眼（primaryopenangleglaucoma，POAG）视网膜外层的结构特征仍有争议，这些改变与视网膜内层的改变一起沿着，可能具有临床和/或病理生理学意义。定制的超高分辨率光学相干断层扫描（UHR-OCT）结合自动分割算法可以对视网膜内的八层进行成像和测量。本研究的目的是确定POAG患者黄斑视网膜内层，特别是外层的厚度特征。POAG患者34例（56眼），正常对照组33例（63眼）。获得以水平和垂直子午线上的中央凹为中心的沿着6 mm长度的8个视网膜内层的厚度分布，并比较两组之间的区域厚度。然后分析视网膜各层厚度与黄斑视野（VF）敏感度之间的关系。POAG不仅累及视网膜内层，还累及视网膜外层的感光细胞层和视网膜色素上皮。而VF的丢失主要与视网膜内层的损害有关。自动算法的UHR-OCT是检测青光眼进展过程中黄斑微结构变化的有用工具。
The structural characteristics of the outer retinal layers in primary open angle glaucoma (POAG) are still controversial, and these changes, along with those in the inner retinal layers, could have clinical and/or pathophysiological significance. A custom-built ultra-high resolution optical coherence tomography (UHR-OCT) combined with an automated segmentation algorithm can image and measure the eight intra-retinal layers. The purpose of this study is to determine the thickness characteristics of the macular intra-retinal layers, especially the outer layers, in POAG patients. Thirty-four POAG patients (56 eyes) and 33 normal subjects (63 eyes) were enrolled. Thickness profiles of the eight intra-retinal layers along a 6-mm length centred on the fovea at the horizontal and vertical meridians were obtained and the regional thicknesses were compared between two groups. The associations between the thicknesses of each intra-retinal layer and the macular visual field (VF) sensitivity were then analysed. POAG affected not only the inner retinal layers but also the photoreceptor layers and retinal pigment epithelium of the outer retina. However, the VF loss was correlated mainly with the damage of the inner retinal layers. UHR-OCT with automated algorithm is a useful tool in detecting microstructural changes of macula with respect to the progression of glaucoma.