Effects of berberine on lipid profile in subjects with low cardiovascular risk
Effects of berberine on lipid profile in subjects with low cardiovascular risk
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DOI：
10.1517/14712598.2013.776037
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发表时间：
2013-04-01
影响因子：
4.6
通讯作者：
Maffioli, Pamela
中科院分区：
文献类型：
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作者：
Derosa, Giuseppe;D'Angelo, Angela;Maffioli, Pamela
目的：研究设计和方法：144例白人受试者入组研究，目的：评价黄连素作为抗高胆固醇血症药物在低心血管风险患者中的疗效。经过6个月的饮食和体力活动后，患者随机服用安慰剂或黄连素500毫克，每天两次，为期3个月，在双盲，安慰剂对照设计。然后中断黄连素和安慰剂治疗2个月（洗脱期），所有患者仅继续饮食和体力活动。在洗脱期结束时，患者重新开始服用黄连素或安慰剂，每天两次，持续3个月。人体测量和代谢参数进行了评估，在运行期间，在随机化，之前和之后的washout period.Results：体重和BMI下降后，观察到的运行期间。与安慰剂相比，随机分组3个月后，黄连素降低了总胆固醇、甘油三酯和LDL胆固醇，增加了HDL胆固醇。洗脱期后，血脂恶化;之后，当小檗碱被重新引入，血脂改善再次与洗脱期相比，和安慰剂。结论：小檗碱是有效的，安全的，以轻度改善血脂在低风险的心血管疾病的受试者。
Objective: To evaluate the efficacy as antihypercholesterolemic agent of berberine in patients with low cardiovascular risk.Research design and methods: 144 Caucasian subjects were enrolled. After a 6-month run-in period following diet and practicing physical activity, patients were randomized to take placebo or berberine 500 mg twice a day, for 3 months, in a double-blind, placebo-controlled design. Berberine and placebo were then interrupted for 2 months (washout period), and all patients continued with only diet and physical activity. At the end of the washout period, patients restarted berberine or placebo twice a day for further 3 months. Anthropometric and metabolic parameters were assessed during the run-in period, at randomization, before and after the washout period.Results: A decrease of body weight and BMI was observed after the run-in period. Berberine reduced total cholesterol, triglycerides and LDL cholesterol and increased HDL cholesterol after 3 months from randomization and compared with placebo. After the washout period, lipid profile worsened; afterward, when berberine was reintroduced, lipid profile improved again both compared with the washout period, and with placebo.Conclusions: Berberine is effective and safe to mildly improve lipid profile in subjects with low risk for cardiovascular disease.