Nitric oxide, ischaemia and brain inflammation.
Nitric oxide, ischaemia and brain inflammation.
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DOI：
10.1042/bst0351133
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发表时间：
2007-11
影响因子：
3.9
通讯作者：
S. Murphy;C. Gibson
中科院分区：
文献类型：
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作者：
S. Murphy;C. Gibson
脑缺血导致NOS（一氧化氮合酶）的三种亚型的激活，这有助于中风病理的发展和恢复。这篇综述特别讨论了转录激活的NOS-2（诱导型NOS）异构体的作用，并总结了关于一氧化氮供体和NOS抑制剂治疗卒中的实验研究结果。
Cerebral ischaemia results in the activation of three isoforms of NOS (nitric oxide synthase) that contribute to the development of and recovery from stroke pathology. This review discusses, in particular, the role of the transcriptionally activated NOS-2 (inducible NOS) isoform and summarizes the outcomes of experimental stroke studies with regard to the therapeutic utility of nitric oxide donors and NOS inhibitors.