RAT FETAL DEVELOPMENT AND MATERNAL EXPOSURE TO TRICHLOROETHYLENE 100 PPM
RAT FETAL DEVELOPMENT AND MATERNAL EXPOSURE TO TRICHLOROETHYLENE 100 PPM
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DOI：
10.1093/bja/54.3.337
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发表时间：
1982-01-01
影响因子：
9.8
通讯作者：
HOPPER, A
中科院分区：
文献类型：
--
作者：
HEALY, TEJ;POOLE, TR;HOPPER, A
近交系Wistar大鼠(32只)从妊娠第8天至第21天，每天暴露于空气中100ppm的三氯乙烯[麻醉剂]4h。对照组(31只)暴露在相同的实验条件下，但不添加三氯乙烯。于妊娠第21天处死大鼠，取卵巢、子宫、肝脏、肺、心脏和胎儿进行组织学检查。没有畸形发生的证据，但胎儿体重减轻(P<；0.005)和两部分或不存在骨骼骨化中心的增加(P<；0.005)表明胎儿成熟延迟。
Inbred Wistar rats (32) were exposed to trichloroethylene [an anesthetic agent] 100 ppm in air for 4 h daily from day 8-21 of pregnancy. A control group (31 rats) was exposed to the same experimental conditions but without the addition of trichloroethylene. All rats were sacrificed on the 21st day of pregnancy, and the ovaries, uterus, liver, lungs, heart and fetuses were examined. There was no evidence of teratogenesis, but a delay in fetal maturation was suggested by reduced fetal weight (P < 0.05) and by an increase in bipartite or absent skeletal ossification centers (P < 0.005).