Influence of restraint stress on ligature-induced periodontitis in rats
Influence of restraint stress on ligature-induced periodontitis in rats
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DOI：
10.1034/j.1600-0722.2002.11153.x
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发表时间：
2002-04-01
影响因子：
1.9
通讯作者：
Skaleric, U
中科院分区：
文献类型：
--
作者：
Gaspersic, R;Stiblar-Martincic, D;Skaleric, U
用丝线结扎法建立Wistar大鼠上颌骨右第二磨牙牙周炎模型，观察压力对牙周组织破坏的影响。将大鼠分为3组，每组10只，第一组束缚应激12hd(-1)，持续4wk，第二组束缚应激2.5hd(-1)，持续4wk，第三组为对照组。结扎4wk可加速牙周组织的降解，而束缚应激本身对牙周组织无明显影响。联合应力和结扎导致的附着体丢失和牙槽骨吸收显著高于任何一种单独处理，而两种应力方案之间没有差异。4wk后，束缚组大鼠体重减轻，束缚12hd(-1)组大鼠胸腺重量减轻，而肾上腺重量和组成无明显变化。我们的结论是，压力本身并不会导致牙周病，但可能会调节已经存在的牙周炎的病理生理过程，导致牙周组织加速降解。
The influence of stress on periodontal breakdown in Wistar rats was analyzed during experimental periodontitis, induced by placing silk ligatures around the maxillary right second molar teeth. The rats were divided into three groups with 10 animals in each; the first group was exposed to restraint stress for 12 h d(-1) for a period of 4 wk; the second group was exposed to restraint stress for 2.5 h d(-1) for a period of 4 wk, the third group served as a control group. Ligation for 4 wk resulted in an accelerated periodontal degradation, whereas the restraint stress by itself had no significant effect. Combined stress and ligation resulted in a significantly higher attachment loss and alveolar bone resorption than either treatment alone, while no differences were seen between the two stress regimens. After 4 wk, a reduced body weight was found in both restrained groups of rats and a reduced weight of the thymus in the rats restrained for 12 h d(-1), while no changes were observed in the weight or composition of the suprarenal glands. We conclude that stress alone does not result in periodontal disease but may modulate the pathophysiological processes of already present periodontal inflammation, resulting in accelerated degradation of periodontal tissues.