Association of dorsal inferior frontooccipital fasciculus fibers in the deep parietal lobe with both reading and writing processes: a brain mapping study
Association of dorsal inferior frontooccipital fasciculus fibers in the deep parietal lobe with both reading and writing processes: a brain mapping study
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DOI：
10.3171/2014.2.jns131234
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发表时间：
2014-07-01
影响因子：
4.1
通讯作者：
Wakabayashi, Toshihiko
中科院分区：
文献类型：
--
作者：
Motomura, Kazuya;Fuji, Masazumi;Wakabayashi, Toshihiko
失读症和失写症是常见于左顶下小叶的疾病，包括角回和缘上回。然而，目前还不清楚这些皮质区域如何与其他皮质部位相互作用，以及最重要的白色物质束与阅读和书写过程的关系。在这里，作者介绍了一个病人的情况下，谁接受了清醒开颅术的左下顶叶胶质瘤使用直接皮层和皮层下电刺激。皮层下刺激的使用允许识别与阅读和书写相关的特定白色物质束。这些纤维束是位于顶叶深部的背侧下额枕束（IFOF）纤维的一部分，负责连接额叶和上级顶叶小叶。这些发现与先前的弥散张量成像纤维束成像和功能性MRI研究一致，这些研究表明IFOF可能在阅读和书写过程中发挥作用。这是第一次报告的短暂失读症和失写症引起的术中直接皮层下电刺激，研究结果支持的关键作用，IFOF的阅读和写作。
Alexia and agraphia are disorders common to the left inferior parietal lobule, including the angular and supramarginal gyri. However, it is still unclear how these cortical regions interact with other cortical sites and what the most important white matter tracts are in relation to reading and writing processes.Here, the authors present the case of a patient who underwent an awake craniotomy for a left inferior parietal lobule glioma using direct cortical and subcortical electrostimulation. The use of subcortical stimulation allowed identification of the specific white matter tracts associated with reading and writing. These tracts were found as portions of the dorsal inferior frontooccipital fasciculus (IFOF) fibers in the deep parietal lobe that are responsible for connecting the frontal lobe to the superior parietal lobule. These findings are consistent with previous diffusion tensor imaging tractography and functional MRI studies, which suggest that the IFOF may play a role in the reading and writing processes. This is the first report of transient alexia and agraphia elicited through intraoperative direct subcortical electrostimulation, and the findings support the crucial role of the IFOF in reading and writing.