Toxicological effects of multi-wall carbon nanotubes in rats
Toxicological effects of multi-wall carbon nanotubes in rats
复制标题
多壁碳纳米管对大鼠的毒理学作用
DOI：
10.1007/s11051-008-9369-0
复制
发表时间：
2008-12-01
影响因子：
2.5
通讯作者：
Zhao, Dongmei
中科院分区：
文献类型：
--
作者：
Liu, Aihong;Sun, Kangning;Zhao, Dongmei
本研究旨在评估多壁碳纳米管（MWCNTs）的肺毒性。本研究工作采用气管内滴注给药方式将多壁碳纳米管暴露于大鼠体内。我们系统地研究了纳米粒子在体内的分布、纳米毒性的靶器官和时间效应、纳米毒性的剂量效应等。这些结果表明，在本次试验条件下，通过气管内滴注使大鼠肺部暴露于多壁碳纳米管，会以剂量依赖和时间依赖的方式产生一系列多种病变，这是一种异物机体反应的证据。
The aim of this study was to evaluate the lung toxicity of multi-wall carbon nanotubes (MWCNTs). The present work exposed MWCNTs into the rats in intratracheal instillation administration modes. We systematically studied the distribution of nanoparticles in vivo, target organs and time-effects of nanotoxicity, dose-effects of nanotoxicity, etc. These results indicate that under the conditions of this test, pulmonary exposures to MWCNTs in rats by intratracheal instillation produced a series of multiple lesions in a dose-dependent and time-dependent manner, evidence of a foreign tissue body reaction.