Regulation of herpes simplex virus-induced thymidine kinase.
Regulation of herpes simplex virus-induced thymidine kinase.
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单纯疱疹病毒诱导的胸苷激酶的调节。
DOI：
10.1016/s0006-291x(74)80491-2
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发表时间：
1974
影响因子：
3.1
通讯作者：
B. Mcauslan
中科院分区：
文献类型：
--
作者：
B. Garfinkle;B. Mcauslan
胸苷激酶在感染 1 型或 2 型单纯疱疹病毒的 XC 细胞中被诱导。病毒胸苷激酶的信使稳定至少 7 小时，并且似乎是早期病毒转录本，但不是在放线菌酮存在下产生的早期早期转录本。激酶合成的终止取决于DNA 合成。在合成足够的 mRNA 以维持最大激酶合成速率和可检测到的激酶活性增加之间存在长达 5 小时的延迟，表明翻译受到调节或酶的激活被延迟。
Thymidine kinase is induced in XC cells infected with herpes simplex type 1 or 2. The messenger for viral thymidine kinase is stable for at least 7 hrs and appears to be an early viral transcript but not a pre-early transcript made in the presence of cycloheximide. Termination of kinase synthesis is dependent upon DNA synthesis. There is a delay of up to 5 hrs between the synthesis of enough mRNA to sustain a maximal rate of kinase synthesis and the increase in detectable kinase activity suggesting that translation is modulated or activation of enzyme is delayed.