Interactions between dendritic cells and CD4+ T cells during Plasmodium infection.
Interactions between dendritic cells and CD4+ T cells during Plasmodium infection.
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DOI：
10.1186/1475-2875-7-88
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发表时间：
2008-05-21
期刊：
影响因子：
3
通讯作者：
Rodriguez A
中科院分区：
文献类型：
--
作者：
Ocaña-Morgner C;Wong KA;Rodriguez A
During infection, dendritic cells (DCs) encounter pathogenic microorganisms that can modulate their function and shape the T cell responses generated. During the process of T cell activation, DCs establish strong, long-lasting interactions with naïve T cells. Using a mouse malaria model, the interactions of DCs and naïve CD4+ T cells have been analysed. DCs, either incubated in vitro with infected erythrocytes or isolated from infected mice, are able to present exogenous antigens by MHC-II, but are not able to establish prolonged effective interactions with naïve CD4+ T cells and do not induce T cell activation. It was also found that effective T cell activation of naïve CD4+ T cells is impaired during late Plasmodium yoelii infection. These data may provide a mechanism for the lack of effective adaptive immune responses induced by the Plasmodium parasite.
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