Ethnic variation in bone turnover in pre- and early perimenopausal women: Effects of anthropometric and lifestyle factors
Ethnic variation in bone turnover in pre- and early perimenopausal women: Effects of anthropometric and lifestyle factors
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DOI：
10.1210/jc.87.7.3051
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发表时间：
2002-07-01
影响因子：
5.8
通讯作者：
Ettinger, B
中科院分区：
文献类型：
--
作者：
Finkelstein, JS;Sowers, M;Ettinger, B
不同种族的妇女骨密度和骨折率各不相同。然而，人们对骨转换的种族差异知之甚少。我们测量了2313名围绝经期妇女的血清骨钙素（OC）和尿I型胶原N-端肽（NTX）水平，这些妇女包括高加索人（n = 1140）、非洲裔美国人（n = 651）、中国人（n = 247）或日本人（n = 275），并参加了全国妇女健康研究。在调整一系列影响骨转换的生活方式和人体测量变量后，比较血清OC和尿NTX水平。未校正的血清OC水平在白人女性中最高（P < 0.001，与所有其他组相比），非洲裔美国人高于中国女性（P = 0.006），中国和日本女性（P = 0.203）与非洲裔美国人和日本女性（P = 0.187）相似。高加索人未经调整的血清OC水平比其他组高11-24%。调整协变量并没有改变血清OC水平的种族模式。两组比较中，白人和非裔美国女性未经校正的尿NTX水平均显著高于中国女性（P < 0.001）。未校正的尿NTX水平在白人高于日本妇女（P = 0.071），日本高于中国妇女（P = 0.055），但这些差异的边缘统计学意义。非裔美国人和高加索人未经校正的尿NTX水平比其他组高9-18%。在高加索人中，血清OC和尿NTX水平存在显著的地理区域差异，来自东北部和中西部的女性高于来自加州的女性。这些数据表明，在围绝经期妇女的前和早期的骨转换显着的种族差异。虽然这些成人骨转换的差异可以解释某些已知的BMD种族差异，但成人骨转换的种族模式与BMD模式并不平行。其他因素，如骨增生的差异，可能是造成成人BMD种族差异的主要原因。
Bone mineral density (BMD) and fracture rates vary among women of differing ethnicities. Little is known, however, about ethnic variation in bone turnover. We measured serum osteocalcin (OC) and urinary N-telopeptide of type I collagen (NTX) levels in 2313 pre- or early perimenopausal women who were Caucasian (n = 1140), African-American (n = 651), Chinese (n = 247), or Japanese (n = 275) and were participating in the Study of Women's Health Across the Nation. Serum OC and urinary NTX levels were compared before and after adjustment for a series of lifestyle and anthropometrie variables that can affect bone turnover. Unadjusted serum OC levels were highest in Caucasian women (P < 0.001 vs. all other groups), higher in African-American than Chinese women (P = 0.006), and similar in Chinese and Japanese women (P = 0.203) and African-American and Japanese women (P = 0.187). Unadjusted serum OC levels were 11-24% higher in Caucasians than in the other groups. Adjustment for covariates did not alter the ethnic pattern of serum OC levels. Unadjusted urinary NTX levels were statistically significantly higher in Caucasian and African-American women than in Chinese women (P < 0.001) for both comparisons. Unadjusted urinary NTX levels were higher in Caucasian than in Japanese women (P = 0.071) and higher in Japanese than in Chinese women (P = 0.055), but these differences were of borderline statistical significance. Unadjusted urinary NTX levels were 9-18% higher in African-Americans and Caucasians than in the other groups. Among Caucasians, there were significant geographic regional variations in both serum OC and urinary NTX levels, with higher levels in women from the Northeast and the Midwest than in women from California. These data demonstrate significant ethnic differences in bone turnover in pre- and early perimenopausal women. Although these differences in adult bone turnover may explain some of the known ethnic variation in BMD, ethnic patterns of adult bone turnover do not parallel patterns of BMD. Other factors, such as differences in bone accretion, are likely responsible for much of the ethnic variation in adult BMD.