Retinal Thickening in Iridocyclitis
Retinal Thickening in Iridocyclitis
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DOI：
10.1016/j.ajo.2009.03.034
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发表时间：
2009-09-01
影响因子：
4.2
通讯作者：
Jaffe, Glenn J.
中科院分区：
文献类型：
--
作者：
Castellano, Chelsea G.;Stinnett, Sandra S.;Jaffe, Glenn J.
目的：测定虹膜睫状体炎患者视网膜增厚（RT）的发生频率，并探讨前房（AC）炎症、RT和视力之间的相关性。设计：回顾性观察性病例系列。方法：回顾2002年1月至2008年3月在杜克大学眼科中心葡萄膜炎诊所就诊的患者记录。包括单侧虹膜睫状体炎，无全葡萄膜炎、玻璃体炎、足底炎、后葡萄膜炎或其组合，并接受双眼光学相干断层扫描（OCT）。记录交流细胞分级和OCT RT测量结果。根据杜克阅读中心的指南，通过OCT扫描确定视网膜下积液和视网膜内囊肿。结果：对43例患者进行了研究。RT典型呈环状分布在中央凹周围。在黄斑总体积（TMV）和所有OCT子场中，研究眼与其他眼在RT中的中位数差异有统计学意义（P < 0.001）。在研究眼中，OCT、TMV的RT与AC细胞等级（P = 0.039; r(2) = 0.1）和OCT外环象限组成的子野（P = 0.027; r(2) = 0.12）之间存在适度相关性，OCT-TMV的RT与视力之间存在适度相关性，除了中心子野（P = 0.003 ~ 0.007; r(2) = 0.261 ~ 0.227）。抗炎治疗后RT降低。结论：RT与虹膜睫状体炎密切相关，治疗后降低。由OCT测定的RT是评估虹膜睫状体炎患者和监测治疗反应的有用临床参数。[J]中华眼科杂志，2009;48(1):341-349。(C) 2009年Elsevier Inc.版权所有。)
PURPOSE: To determine the frequency of retinal thickening (RT) in eyes with iridocyclitis and to examine the correlations among anterior chamber (AC) inflammation, RT, and visual acuity.DESIGN: Retrospective, observational case series.METHODS: Records were reviewed of patients seen at the Duke University Eye Center Uveitis Clinic from January 2002 through March 2008. Patients with unilateral iridocyclitis without panuveitis, vitreitis, pars planitis, posterior uveitis, or a combination thereof who had undergone optical coherence tomography (OCT) of both eyes were included. The AC cell grade and OCT RT measurements were recorded. Subretinal fluid and intraretinal cysts were determined from OCT scans according to Duke Reading Center guidelines.RESULTS: Forty-three patients were studied. RT typically was present in a ring-like distribution around the fovea. The median difference between the study eye and fellow eye in RT was statistically significant for total macular volume (TMV) and for all OCT subfields (P < .001). In the study eye, there was a modest correlation between the RT and AC cell grade for the OCT,TMV (P = .039; r(2) = 0.1) and the subfield comprised of the quadrants in the outer ring on OCT (P = .027; r(2) = 0.12), and between RT and visual acuity for OCT-TMV and all but the central subfields (P = .003 to .007; r(2) = 0.261 to 0.227). RT decreased after anti-inflammatory therapy.CONCLUSIONS: RT is strongly associated with iridocyclitis and decreases after treatment. RT, as determined by OCT, is a useful clinical parameter to evaluate patients with iridocyclitis and to monitor response to treatment. (Am J Ophthalmol 2009;148:341-349. (C) 2009 by Elsevier Inc. All rights reserved.)