A developmental switch in the response of DRG neurons to ETS transcription factor signaling.
A developmental switch in the response of DRG neurons to ETS transcription factor signaling.
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DOI：
10.1371/journal.pbio.0030159
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发表时间：
2005-05
期刊：
影响因子：
9.8
通讯作者：
中科院分区：
文献类型：
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作者：
Pea 3亚家族的两个ETS转录因子在背根神经节（DRG）感觉和脊髓运动神经元的亚群中由靶源性因子诱导。它们的表达控制神经元分化的晚期方面，例如靶向侵入和分支。在这里，我们表明，迟发性ETS基因表达是正常的感觉神经元分化的基本要求。我们提供的遗传学证据表明，在小鼠的早熟ETS在DRG感觉神经元的表达扰乱轴突投射，收购终末分化标志物，和他们的依赖神经营养支持。总之，我们的研究结果表明，DRG感觉神经元表现出时间发育开关，可以揭示不同的反应ETS转录因子信号在神经元成熟的顺序步骤。通过在背根神经节发育的不同发育阶段表达ETS转录因子，作者表明ETS表达的晚发对于正常感觉神经元分化是必不可少的
Two ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal root ganglion (DRG) sensory and spinal motor neurons by target-derived factors. Their expression controls late aspects of neuronal differentiation such as target invasion and branching. Here, we show that the late onset of ETS gene expression is an essential requirement for normal sensory neuron differentiation. We provide genetic evidence in the mouse that precocious ETS expression in DRG sensory neurons perturbs axonal projections, the acquisition of terminal differentiation markers, and their dependence on neurotrophic support. Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation. By expressing ETS transcription factors at different developmental stages of dorsal root ganglion development, the authors show that late onset of ETS expression is essential for normal sensory neuron differentiation