Antiviral activity of mixed-valence rare earth borotungstate heteropoly blues against influenza virus in mice
Antiviral activity of mixed-valence rare earth borotungstate heteropoly blues against influenza virus in mice
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DOI：
10.1177/095632020001100603
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发表时间：
2000-11-01
影响因子：
--
通讯作者：
Tao, PZ
中科院分区：
文献类型：
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作者：
Liu, J;Mei, WJ;Tao, PZ
稀土硼钨酸盐杂多蓝 HPB-2、Ce2H3[(BW9W2Mn)-W-VI-Mn-V(H2O)O-39] 的急性和累积毒性。 12H(2)O对昆明小鼠具有抗流感病毒活性，在昆明小鼠口服和腹腔注射后进行了研究。然后研究了 HPB-2 在小鼠体内对抗流感病毒 (FM1) 的活性。 HPB-2 口服 (p.o.) 或腹膜内 (i.p.) 给药均显示出活性。 HPB-2 被证明比阳性对照利巴韦林更有效，并且还发现腹膜内注射。管理比邮政更有效。行政。
The acute and accumulated toxicity of the rare earth borotungstate heteropoly blues, HPB-2, Ce2H3[(BW9W2Mn)-W-VI-Mn-V(H2O)O-39]. 12H(2)O, which is active against influenza virus in Kunming mice, were investigated in Kunming mice following oral and intraperitoneal administration. The activity of HPB-2 against influenza virus (FM1) in the mice was then investigated. HPB-2, given either orally (p.o.) or intraperitoneally (i.p.), was shown to have activity. HPB-2 was shown to be more effective than the positive control, ribavirin, and it was also found that i.p. administration was more effective than p.o. administration.