Effect of timolol on aqueous humor protein concentration in the human eye.
Effect of timolol on aqueous humor protein concentration in the human eye.
复制标题
噻吗洛尔对人眼房水蛋白浓度的影响。
DOI：
--
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
R. Haddad
中科院分区：
文献类型：
--
作者：
M. Stur;G. Grabner;V. Huber;J. Schreiner;R. Haddad
我们进行了一项双盲、对照研究，研究马来酸噻吗洛尔局部给药后房水中蛋白浓度的增加。本研究纳入了40例计划接受囊内白内障手术的患者。以随机方式局部应用噻吗洛尔滴眼液或噻吗洛尔单独溶媒（对照），并在手术期间收集房水。通过凝胶过滤色谱法测定蛋白质浓度。在噻吗洛尔处理组中，总蛋白浓度以及高分子量和中分子量蛋白的浓度显著升高。三种不同分子量类别的水平的关系在两组之间没有显著差异，表明面对减少的房水产生的未受干扰的蛋白质过滤-而不是血-房水屏障的渗透性的变化-是浓度增加的原因。
We performed a double-masked, controlled study investigating the increase in the protein concentration in aqueous humor after topical timolol maleate administration. Forty patients scheduled to undergo intracapsular cataract surgery were included in the study. Either timolol ophthalmic solution or the vehicle of timolol alone (control) were applied topically in a randomized fashion, and aqueous humor was collected during surgery. Protein concentrations were determined by gel-filtration chromatography. The total protein concentration as well as the concentration of high and medium molecular weight proteins were significantly elevated in the timolol-treated group. The relation of the levels of the three different molecular weight classes did not differ significantly between the two groups, indicating that undisturbed protein filtration in the face of reduced aqueous humor production--and not a change in the permeability of the blood-aqueous barrier--is responsible for the increase in concentration.
二维扫描目镜荧光光度计。
影响因子：
4.4
作者：
McLaren,JW;Brubaker,RF
通讯作者：
Brubaker,RF