The role of copper in drug-resistant murine and human tumors
The role of copper in drug-resistant murine and human tumors
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DOI：
10.1007/s10534-008-9174-3
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发表时间：
2009-04-01
期刊：
影响因子：
3.5
通讯作者：
Choudhuri, Soumitra Kumar
中科院分区：
文献类型：
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作者：
Majumder, S.;Chatterjee, S.;Choudhuri, Soumitra Kumar
多药耐药（MDR）仍然是肿瘤化疗药物临床应用的主要威胁。铜在生物系统中起着重要作用，铜也参与致癌作用。在本研究中，我们解决了金属铜是否可能参与小鼠和人类肿瘤的耐药性的问题。通过原子吸收光谱法，我们测定血清铜浓度。我们发现，荷瘤小鼠的血清中铜含量高于健康的荷瘤小鼠。第二，阿霉素耐药的埃利希腹水癌或环磷酰胺耐药的刘易斯肺癌小鼠的血清铜含量高于相应的药物敏感的亲本肿瘤小鼠。此外，对乳腺癌、结肠癌或肺癌患者的分析表明，与肿瘤对治疗有反应的患者相比，对化疗无反应的患者的血清铜含量更高。健康志愿者血清中的铜水平低于癌症患者，无论他们对化疗的反应如何。我们的研究结果表明，血清铜水平可能被认为是治疗反应的生物标志物。
Multidrug resistance (MDR) is still a major threat to successful clinical application of cancer chemotherapy. Copper plays an important role in biological systems, and copper is also involved in carcinogenesis. In the present investigation, we addressed the question whether metal copper might be involved in drug resistance of murine and human tumors. By means of atomic absorption spectroscopy, we determined serum copper concentrations. We found that the blood serum of tumor-bearing mice contained higher amounts of copper than healthy mice with tumors. Secondly, mice bearing doxorubicin-resistant Ehrlich ascites carcinoma- or cyclophosphamide-resistant Lewis lung carcinoma contained more copper in their serum than mice bearing the corresponding drug-sensitive parental tumors. Furthermore, the analysis of patients with breast cancer, colon carcinoma or lung cancer showed that the serum copper contents were higher in patients not responding to chemotherapy when compared to patients whose tumors responded to treatment. The copper levels in serum of healthy volunteers were lower than in cancer patients irrespective of their response to chemotherapy. Our results imply that the level of serum copper may be considered as a biomarker for treatment response.