Phenolic acids and their glycosides from the rhizomes of Cimicifuga dahurica
Phenolic acids and their glycosides from the rhizomes of Cimicifuga dahurica
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升麻根茎中的酚酸及其苷类
DOI：
10.1016/j.fitote.2019.03.023
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发表时间：
2019-04-01
期刊：
影响因子：
3.4
通讯作者：
Yao, Xin-Sheng
中科院分区：
文献类型：
--
作者：
Lu, Qing;Zhang, Wei-Yang;Yao, Xin-Sheng
通过对白升麻根茎的植物化学研究，分离得到9个新的新木脂素和苯丙素苷，分别为升麻皂苷A-E(1，2，7-9)、升麻糖苷B-D(3-5)、升麻糖苷G(6)和4个已知化合物(10-13)。通过广泛的波谱分析(一维、二维核磁共振、MS、CD、IR、UV)和化学方法鉴定了它们的结构。通过测定它们对脂多糖刺激的RAW264.7细胞产生PGE2的影响来评价它们的抗炎作用，化合物12和13具有中等的抗炎活性。
Phytochemical study on rhizomes of Cimicifuga dahurica resulted in the isolation of nine new neolignan and phenylpropanoid glycosides, cimicifugasides A-E (1, 2, 7-9), cimicifugamides B-D (3-5), shomaside G (6) along with four known compounds (10-13). Their structures were identified by extensive spectroscopic analyses (1D-, 2D-NMR, MS, CD, IR, UV) and chemical methods. Their anti-inflammatory potentials were evaluated by measuring their effects on PGE2 production of LPS-stimulated RAW264.7 cells, and compounds 12 and 13 showed moderate anti-inflammatory activities.