Convergent integration of animal model and human studies of bipolar disorder (manic-depressive illness)
Convergent integration of animal model and human studies of bipolar disorder (manic-depressive illness)
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DOI：
10.1016/j.coph.2010.08.008
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发表时间：
2010-10-01
影响因子：
4
通讯作者：
Niculescu, Alexander B.
中科院分区：
文献类型：
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作者：
Le-Niculescu, Helen;Patel, Sagar D.;Niculescu, Alexander B.
由于最近的成功，双相情感障碍和其他精神疾病的动物模型和人体研究正变得越来越一体化。特别是对于基因组学而言，跨物种、实验模式和技术平台的数据融合和整合正在提供一种适合疾病的方式来提取可重复且具有生物学意义的重要信号，这与队列效应、迄今为止令人失望的发现以及仅人类遗传分析的可重复性有限形成鲜明对比。精神病学方面的此类工作可以提供如何解决其他复杂遗传疾病的示例，反过来也将通过整合其他领域的概念（例如癌症生物学和糖尿病）而受益。
Animal models and human studies of bipolar disorder and other psychiatric disorders are becoming increasingly integrated, prompted by recent successes. Particularly for genomics, the convergence and integration of data across species, experimental modalities and technical platforms is providing a fit-to-disease way of extracting reproducible and biologically important signal, in sharp contrast to the fit-to-cohort effect, disappointing findings to date, and limited reproducibility of human genetic analyses alone. Such work in psychiatry can provide an example of how to address other genetically complex disorders, and in turn will benefit by incorporating concepts from other areas, such as cancer biology and diabetes.