Type I interferon signature in the initiation of the immune response in vitiligo
Type I interferon signature in the initiation of the immune response in vitiligo
复制标题
DOI：
10.1111/pcmr.12219
复制
发表时间：
2014-05-01
影响因子：
4.3
通讯作者：
Seneschal, Julien
中科院分区：
文献类型：
--
作者：
Bertolotti, Antoine;Boniface, Katia;Seneschal, Julien
在进展性白癜风的脱色斑块边缘，持续观察到免疫介导的反应。除了适应性免疫系统的作用外，先天免疫反应的轮廓现在是舞台的中心。我们报道，血浆细胞样树突状细胞(PDC)是干扰素(干扰素)α产生的主要细胞，是进行性白癜风局部产生MxA(干扰素诱导的一种蛋白)的浸润物的一部分。MXA与I型干扰素诱导配体CXCL9的表达相关，与CXCR3(+)免疫细胞的募集相关。有趣的是，在皮损周围的皮肤中观察到强烈的MXA表达，与残留的黑素细胞接近，周围有明显的T细胞浸润物。相比之下，在皮损皮肤中检测不到MXA，这表明干扰素的产生是疾病进展的早期事件。我们的数据强调了导致白癜风进展的一种新的先天免疫途径。
Immune-mediated responses are consistently observed in progressing vitiligo at the edge of depigmenting patches. Besides the role of the adaptive immune system, the profile of the innate immune response is now at the center of the stage. We report that plasmacytoid dendritic cells (pDC), which are the major interferon (IFN)-alpha-producing cells, are part of the infiltrate of progressive vitiligo with local production of MxA (a protein induced by IFN). MxA was associated with expression of the type I IFN-inducible ligand CXCL9 and correlated with the recruitment of CXCR3(+) immune cells. Interestingly, strong MxA expression was observed in perilesional skin in close apposition to remaining melanocytes, surrounded by a prominent T-cell infiltrate. In contrast, MxA was not detectable in lesional skin, suggesting that IFN- production is an early event in the progression of the disease. Our data highlight a new innate immune pathway leading to progression of vitiligo.