International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results.
International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results.
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DOI：
10.1007/s13317-016-0075-0
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发表时间：
2016-12
期刊：
影响因子：
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通讯作者：
Conrad K
中科院分区：
文献类型：
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作者：
Damoiseaux J;von Mühlen CA;Garcia-De La Torre I;Carballo OG;de Melo Cruvinel W;Francescantonio PL;Fritzler MJ;Herold M;Mimori T;Satoh M;Andrade LE;Chan EK;Conrad K
关于ANA模式的国际共识(ICAP)是作为一个研讨会发起的，旨在深入讨论并就在Hep-2细胞的间接免疫荧光分析中观察到的形态模式达成共识。在ICAP第二次研讨会上讨论并在本文件中讨论的主题之一是统一报告ANA测试结果。讨论集中在细胞质和有丝分裂模式是否应该被报告为阳性或阴性的问题上。本报告概述了影响两种主要不同报告方法的问题。尽管所有与会者都认识到细胞质和有丝分裂模式在临床上是相关的，但对ANA相关疾病的现有诊断/分类标准的影响尤其阻碍了对这一专题的最终共识。显然，需要所有相关利益攸关方采取更协调一致的行动。ICAP今后的讲习班可能有助于促进这一行动。
The International Consensus on ANA Patterns (ICAP) was initiated as a workshop aiming to thoroughly discuss and achieve consensus regarding the morphological patterns observed in the indirect immunofluorescence assay on HEp-2 cells. One of the topics discussed at the second ICAP workshop, and addressed in this paper, was the harmonization of reporting ANA test results. This discussion centered on the issue if cytoplasmic and mitotic patterns should be reported as positive or negative. This report outlines the issues that impact on two major different reporting methods. Although it was appreciated by all participants that cytoplasmic and mitotic patterns are clinically relevant, implications for existing diagnostic/classification criteria for ANA-associated diseases in particular hampered a final consensus on this topic. Evidently, a more concerted action of all relevant stakeholders is required. Future ICAP workshops may help to facilitate this action.