Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [11C]ABP688
Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [11C]ABP688
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DOI：
10.1038/tp.2015.189
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发表时间：
2015-12-08
影响因子：
6.8
通讯作者：
Parsey, R. V.
中科院分区：
文献类型：
--
作者：
DeLorenzo, C.;Sovago, J.;Parsey, R. V.
代谢型谷氨酸受体亚型 5 (mGluR5) 与情绪和焦虑障碍的病理生理学有关，是重度抑郁症 (MDD) 的潜在治疗靶点。本研究使用正电子发射断层扫描 (PET) 和 [C-11] ABP688 比较了患有 MDD 的老年患者与老年健康志愿者的大脑 mGluR5 结合。 20 名患有 MDD 的老年人（平均年龄：63.0 +/- 6.3）和 22 名相同年龄范围的健康志愿者（平均年龄：66.4 +/- 7.3）在单次推注 [C-11]ABP688 后接受 PET 检查，其中许多人接受了动脉采样。对感兴趣区域和体素水平分析 PET 图像，以比较两组之间大脑中 mGluR5 的结合。还评估了早发性抑郁症患者和晚发性抑郁症患者之间 [C-11]ABP688 结合的差异。与之前发表的年轻队列报告相比，患有 MDD 的老年受试者和健康志愿者之间的 [C-11]ABP688 结合没有观察到显着差异。 [C-11]ABP688 结合在早发或晚发抑郁症亚组之间也相似。我们相信这是第一项检查老年人抑郁症中 mGluR5 表达的研究。尽管还需要进一步的工作，但结果表明老年抑郁症与早期抑郁症的病理生理学存在潜在差异。
The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in the pathophysiology of mood and anxiety disorders and is a potential treatment target in major depressive disorder (MDD). This study compared brain mGluR5 binding in elderly patients suffering from MDD with that in elderly healthy volunteers using positron emission tomography (PET) and [C-11] ABP688. Twenty elderly (mean age: 63.0 +/- 6.3) subjects with MDD and twenty-two healthy volunteers in the same age range (mean age: 66.4 +/- 7.3) were examined with PET after a single bolus injection of [C-11]ABP688, with many receiving arterial sampling. PET images were analyzed on a region of interest and a voxel level to compare mGluR5 binding in the brain between the two groups. Differences in [C-11]ABP688 binding between patients with early-and late-onset depression were also assessed. In contrast to a previously published report in a younger cohort, no significant difference in [C-11]ABP688 binding was observed between elderly subjects with MDD and healthy volunteers. [C-11]ABP688 binding was also similar between subgroups with early-or late-onset depression. We believe this is the first study to examine mGluR5 expression in depression in the elderly. Although future work is required, results suggest potential differences in the pathophysiology of elderly depression versus depression earlier in life.