Improvement in interstitial cystitis symptom scores during treatment with oral L-arginine.
Improvement in interstitial cystitis symptom scores during treatment with oral L-arginine.
复制标题
口服 L-精氨酸治疗期间间质性膀胱炎症状评分得到改善。
DOI：
10.1097/00005392-199709000-00005
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Weiss,RM
中科院分区：
文献类型：
--
作者：
Smith,SD;Wheeler,MA;FosterJr,HE;Weiss,RM
PurposeUrinary nitric oxide synthase activity is decreased in patients with interstitial cystitis. Since nitric oxide may be an important determinant of the symptoms and immunological responses associated with interstitial cystitis, patients with this disease were treated with oral L-arginine, the substrate for nitric oxide synthase.Materials and MethodsTen patients took 1.5 gm. L-arginine orally daily for 6 months. Interstitial cystitis symptoms were surveyed before and during the 6-month trial.ResultsOral L-arginine treatment resulted in a significant decrease in urinary voiding discomfort, lower abdominal pain and vaginal/urethral pain. Urinary frequency during the day and night also significantly decreased.ConclusionsThis self-controlled study provides evidence that long-term oral L-arginine improves interstitial cystitis related symptoms.
