INCREASED GALACTOSE CLEARANCE AFTER LIVER-TRANSPLANTATION - A MEASURE OF INCREASED BLOOD-FLOW THROUGH THE DENERVATED LIVER
INCREASED GALACTOSE CLEARANCE AFTER LIVER-TRANSPLANTATION - A MEASURE OF INCREASED BLOOD-FLOW THROUGH THE DENERVATED LIVER
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DOI：
10.1002/hep.1840100306
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发表时间：
1989-09-01
期刊：
影响因子：
13.5
通讯作者：
WARREN, WD
中科院分区：
文献类型：
--
作者：
HENDERSON, JM;MILLIKAN, WJ;WARREN, WD
本研究测量了肝移植患者半乳糖清除率的肝血流量依赖性指数，以检验去神经肝脏血流量增加的假设。8例正常人和16例肝移植术后1 ~ 8个月的患者。所有患者在研究时均稳定，无严重排斥反应的证据。在连续输注75 mg/min 5%半乳糖期间，在稳态下测量半乳糖清除率。结果显示，移植患者的平均半乳糖清除率（1，187 ± 0.01）在统计学上显著（p < 0.01）更高。316 ml/min/m2）与对照组（709 . ±. 121 ml/min/m2）。低浓度半乳糖清除的主要限制因素是肝血流量，我们将这些数据解释为移植肝血流量增加的证据。半乳糖清除率增加的可能机制是（i）失神经肝脏中正常血管紧张素的丧失，或（ii）移植后异常的全身血流动力学持续存在。这些机制有待进一步研究。
This study measured the liver blood flow-dependent index of galactose clearance in patients after liver transplantation, to test the hypothesis that liver blood flow is increased in the denervated liver. Eight normal subjects and 16 patients 1 to 8 months after liver transplant were studied. All patients were stable with no evidence of severe rejection at the time of study. Galactose clearance was measured at steady state during continuous infusion of 75 mg per min of 5% galactose. The results show a statistically significant (p < 0.01) higher average galactose clearance in the transplant patients (1,187 .+-. 316 ml per min per m2) compared to the control group (709 .+-. 121 ml per min per m2). The major limiting factor in galactose clearance at low concentrations is liver blood flow and we interpret these data as evidence for increased blood flow in the transplanted liver. Possible mechanisms for the increased galactose clearance are (i) loss of normal vasomotor tone in the denervated liver, or (ii) persistence of abnormal systemic hemodynamics after transplantation. Elucidation of these mechanisms awaits further study.