How to tweak a beak: molecular techniques for studying the evolution of size and shape in Darwin's finches and other birds.
How to tweak a beak: molecular techniques for studying the evolution of size and shape in Darwin's finches and other birds.
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如何调整喙：研究达尔文雀和其他鸟类大小和形状进化的分子技术。
作者：
R. Schneider
在过去十年中，分子、细胞和发育生物学的一系列技术进步使人们对表型多样化的机制有了更清楚的了解。在这种势头的基础上，最近的一篇论文解决了进化中最重要的话题之一，即达尔文雀中物种特异性喙形态的起源。1以前涉及驯养和野生鸟类的工作涉及一个众所周知的信号通路（即骨形态发生蛋白）和一群祖细胞，（即颅神经嵴），作为确定喙大小和形状的主要因素。但这些结果在充分解释模式化生长的形态发生基础方面是有限的。因此，为了寻找表达与达尔文雀喙解剖结构差异相关的新基因，我们使用从加拉帕戈斯群岛采集的组织进行了DNA微阵列方法。结果是惊人的，并指出一种名为钙调蛋白的蛋白质，它是细胞钙信号传导的介质，是鸟喙长度的关键决定因素。
A flurry of technological advances in molecular, cellular and developmental biology during the past decade has provided a clearer understanding of mechanisms underlying phenotypic diversification. Building upon such momentum, a recent paper tackles one of the foremost topics in evolution, that is the origin of species-specific beak morphology in Darwin's finches.1 Previous work involving both domesticated and wild birds implicated a well-known signaling pathway (i.e. bone morphogenetic proteins) and one population of progenitor cells in particular (i.e. cranial neural crest), as primary factors for establishing beak size and shape. But these results were limited in their ability to explain fully the morphogenetic bases of patterned outgrowth. So in a quest to identify novel genes whose expression correlated with differences in beak anatomy among Darwin's finches, a DNA microarray approach was undertaken using tissues harvested from the Galápagos Islands. The results are striking and point to a protein called calmodulin, which is a mediator of cellular calcium signaling, as a key determinant of beak length.
局部视黄醇信号传导通过维持 FGF8 和 SHH 来协调前脑和面部形态发生。
DOI：
10.1242/dev.128.14.2755
发表时间：
2001
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Schneider,RA;Hu,D;Rubenstein,JL;Maden,M;Helms,JA
通讯作者：
Helms,JA