Nosocomial spread of OXA-232-producing Klebsiella pneumoniae ST15 in a teaching hospital, Shanghai, China
Nosocomial spread of OXA-232-producing Klebsiella pneumoniae ST15 in a teaching hospital, Shanghai, China
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DOI：
10.1186/s12866-019-1609-1
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发表时间：
2019-10-28
期刊：
影响因子：
4.2
通讯作者：
Li, Boan
中科院分区：
文献类型：
--
作者：
Li, Xin;Ma, Wei;Li, Boan
背景资料：产OXA-48样碳青霉烯酶的肠杆菌科细菌在我国的传播和暴发越来越普遍。肺炎克雷伯氏菌（OXA 232 Kp）在2015年至2017年期间分离。在烧伤ICU中观察到OXA 232 Kp的爆发。62株OXA 232 Kp菌株均属于ST 15型，分为A、B型。A型占绝对优势，临床分离株61株，分为A1 ~ A10 10个亚型。此外，大多数OXA 232 Kp菌株表现出低水平的碳青霉烯类耐药。所有菌株均携带6141 bp的ColKP 3质粒，该质粒携带bla（OXA-232）基因，与华东地区其他研究中发现的携带bla（OXA-232）基因的质粒高度同源。bla（OXA-232）基因携带质粒之间高度同源性表明，6.1kb ColE样质粒在中国bla（OXA-232）基因的流行中起重要作用。
Background: The spread and outbreak of Enterobacteriaceae producing OXA-48-like carbapenemases have become more and more prevalent in China.Results: A total of 62 non-duplicated OXA-232-producing K. pneumoniae (OXA232Kp) were isolated between 2015 and 2017. An outbreak of OXA232Kp was observed in burn ICU. The 62 OXA232Kp isolates were all belongs to ST15 and categorized into two PFGE types (A and B). Type A was dominated of the isolates, which contained 61 clinical isolates and divided into 10 subtypes (A1-A10). In addition, most of OXA232Kp strains exhibited low-level carbapenems resistance. All strains carried a 6141 bp ColKP3 plasmid harboring the bla(OXA-232) gene which is highly homologous to other bla(OXA-232)-bearing plasmids involved in other studies in eastern China.Conclusions: In this study, clone transmission of OXA232Kp ST15 was observed. Highly significant homology among the bla(OXA-232)-bearing plasmids indicated the important role of the 6.1 kb ColE-like plasmid on the prevalence of bla(OXA-232) gene in China.