Design of a Self-Regulated Drug Delivery Device
Design of a Self-Regulated Drug Delivery Device
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DOI：
10.1023/a:1011494008729
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发表时间：
2001-06-01
影响因子：
2.8
通讯作者：
Lee, L. James
中科院分区：
文献类型：
--
作者：
Cao, Xia;Lai, Siyi;Lee, L. James
大多数常规药物递送系统基于聚合物或脂质囊泡。这些化学合成的材料可以被设计成生物相容性的并且具有良好的功能性，但是由于化学合成产生的固有尺寸和结构分布，它们通常缺乏明确定义的特性。另一方面，为微电子应用开发的微制造技术能够机械地产生具有更精确限定的特征的装置，其尺寸范围类似于聚合物和脂质材料。在本文中，我们描述了一种基于机械和化学方法相结合的自调节给药装置的设计。在该装置中，通过仔细设计药物储存器的形状可以实现恒定的释放速率，同时使用pH敏感的水凝胶开关来调节药物释放。
Most conventional drug delivery systems are based on polymers or lipid vesicles. These chemically synthesized materials can be designed to be biocompatible and have good functionality, but they often lack well-defined properties, due to an inherent size and structure distribution resulting from chemical synthesis. On the other hand, micro-fabrication technology developed for microelectronic applications is capable of mechanically creating devices with more precisely defined features, in a size range similar to polymeric and lipid materials. In this paper, we describe the design of a self-regulated drug delivery device based on the integration of both mechanical and chemical methods. In this device, a constant release rate can be achieved by carefully designing the shape of the drug reservoir, while a pH-sensitive hydrogel switch is used to regulate the drug release.