B-cell infiltrates induce endosteal bone formation in inflammatory arthritis
B-cell infiltrates induce endosteal bone formation in inflammatory arthritis
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DOI：
10.1359/jbmr.080508
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发表时间：
2008-10-01
影响因子：
6.2
通讯作者：
Schett, Georg
中科院分区：
文献类型：
--
作者：
Haver, Silvia;Polzer, Karin;Schett, Georg
本研究的目的是探讨在受炎性关节炎影响的关节附近发现的炎性骨髓浸润物的功能。这些骨髓浸润物富含B细胞，并出现在骨髓和滑膜炎性组织之间的间期。皮质骨断裂的地方我们删除了B细胞发育的一个重要分子。Brutons酪氨酸激酶（Btk），并研究其对骨髓炎症的影响。虽然抗原反应，免疫球蛋白水平。Btk（-/-）hTNFtg小鼠中自身抗体产生减少。滑膜炎症发展正常。然而，骨髓浸润在Btk（-/-）hTNFtg小鼠中显著减少，这导致骨侵蚀下方的骨内膜部位的骨形成受损和滑膜炎性细胞向骨髓中的侵袭增加。Btk（-/-）hTNFtg小鼠骨形态发生蛋白-7的表达显著降低。这些结果不仅表明骨内膜区域的骨形成与骨髓炎症是由B细胞驱动的，而且还表明在炎症关节附近的骨髓聚集体似乎试图抵抗炎症组织侵入骨髓。
The objective of this study wits to investigate the function of inflammatory bone marrow infiltrates found in vicinity to joints affected by inflammatory arthritis. These bone marrow infiltrates are rich in B cells and emerge at the interphase between bone marrow and synovial inflammatory tissue. where cortical bone has been broken. We deleted an essential molecule of B-cell development. Brutons tyrosine kinase (Btk), in arthritic TNF-transgenic mice and studied its effect on bone marrow Inflammation. Although antigen responses, immunoglobulin levels. and autoantibody production were diminished in Btk(-/-)hTNFtg mice. synovial Inflammation developed normally. However, hone marrow infiltrates were significantly diminished ill Btk(-/-)hTNFtg mice, which lead to impaired bone formation at endosteal sites underneath hone erosions and an increased invasion of synovial inflammatory cells into the hone marrow. Expression of bone morphogenic protein-7 was dramatically decreased in Btk(-/-)hTNFtg mice. These results do not only indicate that hone formation at endosteal regions next to bone marrow Infiltrates is driven by B cells but also show that bone marrow aggregates In the vicinity of inflamed joint appear its all attempt to counter the invasion of inflammatory tissue into the bone marrow.