Acute respiratory diseases and carboxyhemoglobin status in school children of Quito, Ecuador.
Acute respiratory diseases and carboxyhemoglobin status in school children of Quito, Ecuador.
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厄瓜多尔基多学童的急性呼吸道疾病和羧基血红蛋白状态。
DOI：
10.1289/ehp.7494
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发表时间：
2005-05
影响因子：
10.4
通讯作者：
Naumova, Elena N
中科院分区：
文献类型：
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作者：
Estrella, Bertha;Estrella, Ramiro;Oviedo, Jorge;Narvaez, Ximena;Reyes, Maria T;Gutierrez, Miguel;Naumova, Elena N
户外碳一氧化碳主要来自车辆的排放，高浓度在交通拥堵的地区与血红蛋白结合，形成羧基蛋白（COHB），并减少了氧气递送。使用COHB作为慢性CO的标记，我们检查了居住在厄瓜多尔市基多市的城市和郊区的学龄儿童中的急性呼吸道感染（ARIS）和COHB浓度。强度和招募的960名儿童以调整潜在的混杂因素，我们在295个儿童的随机子样本中进行了详细的调查 - 在低，中等和高流量的儿童中，人流的浓度高于安全水平的儿童比例为1、43和92％。 [95％的置信区间（CI），1.65–6.38]具有ARI的可能性比COHB <2.5％的儿童高，而COHB的每百分比都高于安全水平，儿童为1.15（95％CI，1.03– 1.28）我们的发现更有可能增加ARI的案例。
Outdoor carbon monoxide comes mainly from vehicular emissions, and high concentrations occur in areas with heavy traffic congestion. CO binds to hemoglobin, forming carboxyhemoglobin (COHb), and reduces oxygen delivery. We investigated the link between the adverse effects of CO on the respiratory system using COHb as a marker for chronic CO exposure. We examined the relationship between acute respiratory infections (ARIs) and COHb concentrations in school-age children living in urban and suburban areas of Quito, Ecuador. We selected three schools located in areas with different traffic intensities and enrolled 960 children. To adjust for potential confounders we conducted a detailed survey. In a random subsample of 295 children, we determined that average COHb concentrations were significantly higher in children attending schools in areas with high and moderate traffic, compared with the low-traffic area. The percentage of children with COHb concentrations above the safe level of 2.5% were 1, 43, and 92% in low-, moderate-, and high-traffic areas, respectively. Children with COHb above the safe level are 3.25 [95% confidence interval (CI), 1.65–6.38] times more likely to have ARI than children with COHb < 2.5%. Furthermore, with each percent increase in COHb above the safety level, children are 1.15 (95% CI, 1.03–1.28) times more likely to have an additional case of ARI. Our findings provide strong evidence of the relation between CO exposure and susceptibility to respiratory infections.