Emerging Roles of Platelets in Allergic Asthma.
Emerging Roles of Platelets in Allergic Asthma.
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DOI：
10.3389/fimmu.2022.846055
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
过敏性哮喘是一种复杂的气道慢性炎症性疾病，由Th 2免疫应答驱动，其特征在于嗜酸性粒细胞性肺部炎症、气道高反应性、过度粘液产生和气道重塑。在动物模型和过敏性哮喘患者的研究中，压倒性的证据表明血小板被异常激活并被招募到肺部。血小板可与其他免疫细胞相互作用并分泌多种生化介质，促进过敏性致敏和气道炎症反应，血小板缺乏可减轻过敏性哮喘的病理特征和症状。然而，血小板在过敏性哮喘中的综合作用尚未完全阐明，使抗血小板药物治疗过敏性哮喘的尝试受到质疑。在这篇综述中，我们总结了血小板活化和肺蓄积在过敏性哮喘中的作用;重点是血小板与关键免疫细胞类型之间的不同相互作用以及血小板源性介质在此背景下的贡献。此外，临床抗血小板治疗过敏性哮喘的方法进行了讨论。本文综述了血小板在变应性哮喘发病机制中的作用，为变应性哮喘的治疗提供了新的思路。
Allergic asthma is a complex chronic inflammatory disease of the airways, driven by Th2 immune responses and characterized by eosinophilic pulmonary inflammation, airway hyperresponsiveness, excessive mucus production, and airway remodeling. Overwhelming evidence from studies in animal models and allergic asthmatic patients suggests that platelets are aberrantly activated and recruited to the lungs. It has been established that platelets can interact with other immune cells and secrete various biochemical mediators to promote allergic sensitization and airway inflammatory response, and platelet deficiency may alleviate the pathological features and symptoms of allergic asthma. However, the comprehensive roles of platelets in allergic asthma have not been fully clarified, leaving attempts to treat allergic asthma with antiplatelet agents questionable. In this review, we summarize the role of platelet activation and pulmonary accumulation in allergic asthma; emphasis is placed on the different interactions between platelets with crucial immune cell types and the contribution of platelet-derived mediators in this context. Furthermore, clinical antiplatelet approaches to treat allergic asthma are discussed. This review provides a clearer understanding of the roles of platelets in the pathogenesis of allergic asthma and could be informative in the development of novel strategies for the treatment of allergic asthma.
影响因子：
3.7
作者：
Yang B;Shi J;Chen X;Ma B;Sun H
通讯作者：
Sun H