A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes
A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes
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DOI：
10.1073/pnas.182314699
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发表时间：
2002-09-03
影响因子：
11.1
通讯作者：
Schartl, M
中科院分区：
文献类型：
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作者：
Nanda, I;Kondo, M;Schartl, M
决定雄性或雌性发育的基因在秀丽隐杆线虫、果蝇和大多数哺乳动物中是已知的。在许多其他生物中，性别决定因素的存在已被遗传证据所证明，但基因是未知的。我们已经发现，在青鳉鱼的Y染色体特异性区域跨度只有约280 kb。它含有一个重复的常染色体DMRT 1基因，命名为DMRT 1 Y。这是该染色体片段中唯一的功能基因，并精确地映射到男性性别决定基因座。该基因在雄性胚胎和幼虫发育期间以及成年睾丸的支持细胞中表达。这些特征使DMRT1 Y成为青鳉雄性性别决定基因的候选者。
The genes that determine the development of the male or female sex are known in Caenorhabditis elegans, Drosophila, and most mammals. In many other organisms the existence of sex-determining factors has been shown by genetic evidence but the genes are unknown. We have found that in the fish medaka the Y chromosome-specific region spans only about 280 kb. It contains a duplicated copy of the autosomal DMRT1 gene, named DMRT1 Y. This is the only functional gene in this chromosome segment and maps precisely to the male sex-determining locus. The gene is expressed during male embryonic and larval development and in the Sertoli cells of the adult testes. These features make DMRT1 Y a candidate for the medaka male sex-determining gene.