The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection
The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection
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DOI：
10.1111/j.1365-2893.2005.00652.x
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发表时间：
2006-01-01
影响因子：
2.5
通讯作者：
Spengler, U
中科院分区：
文献类型：
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作者：
Nattermann, J;Ahlenstiel, G;Spengler, U
C型凝集素DC-SIGNR已被证明与丙型肝炎病毒（HCV）结合。在这里，我们分析了DC-SIGNR基因的串联重复多态性与个体内HCV复制的关系。在横断面比较中，使用PCR对hcv感染患者（n = 430）和健康受试者（n = 100）进行DC-SIGNR多态性基因分型。DC-SIGNR等位基因的分布在两组间无显著差异。然而，携带5、6、7重复等位基因的hcv感染者的HCV-RNA水平高于携带4、9重复等位基因的hcv感染者（P < 0.05）。因此，DC-SIGNR多态性可能影响HCV负荷，支持DC-SIGNR有助于HCV复制效率的概念。
The C-type lectin DC-SIGNR has been shown to bind hepatitis C virus (HCV). Here, we analysed the tandem-repeat polymorphism of the DC-SIGNR gene with respect to intraindividual HCV replication. In a cross-sectional comparison HCV-infected patients (n = 430) and healthy subjects (n = 100) were genotyped for the DC-SIGNR polymorphism using PCR. The distribution of DC-SIGNR alleles did not differ significantly between the two groups. However, HCV-infected patients with 5-, 6-, and 7-repeat alleles had higher HCV-RNA levels when compared with carriers of 4- and 9-repeat alleles (P < 0.05). Thus, the DC-SIGNR polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy.