DEVELOPMENT OF EEG IN RAT
DEVELOPMENT OF EEG IN RAT
复制标题
DOI：
10.1002/dev.420090604
复制
发表时间：
1976-01-01
影响因子：
2.2
通讯作者：
GRAMSBERGEN, A
中科院分区：
文献类型：
--
作者：
GRAMSBERGEN, A
在9-30天龄的Lister品系的白色和黑色带帽大鼠中研究了EEG，特别是行为状态特异性EEG模式的发育。记录大鼠的运动，并通过按钮装置监测行为状态。当大鼠处于状态1（规则呼吸，没有运动，并且在第14天之后当大鼠眼睛睁开时，眼睛闭上）、状态2（不规则呼吸，抽搐持续发生，并且在第14天之后眼睛闭上）和状态4（不规则呼吸，存在全身运动，并且在第14天之后眼睛睁开）时收集EEG。第9天和第10天大鼠的脑电图没有显示出特定的行为状态模式。EEG的振幅较低，仅出现低频。在第10 - 13天之间，出现了特定于包含高振幅的状态1的EEG模式。从第14天开始，在状态1期间，EEG中出现纺锤波（频率为14-18 Hz）。从第14天开始，在状态2期间来自视觉皮层的EEG显示出规则且持续发生的5 Hz节律。在状态4期间，仅间歇性地从视觉皮质记录到5 Hz波的爆发。从第17天开始，爆发期间的EEG频率在5-7 Hz之间变化。振幅分布的计算机分析表明，功率在第10天后有相当大的增加。频谱分析表明，功率增加尤其发生在脑电信号的较高频率处。EEG的视觉和计算机分析没有显示EEG在第18天后的系统性变化，此时EEG与老年时记录的EEG相似。
The development of the EEG and, especially, behavioral state-specific EEG patterns was studied in white and black hooded rats of the Lister strain, aged 9-30 days. Movements of the rat were recorded and the behavioral state was monitored by means of a push-button device. The EEG was collected when the rat was in state 1 (regular respiration, absence of movements, and, after the 14th day when the rat eye opens, eyes closed), state 2 (irregular respiration, continual occurrence of twitches, and, after the 14th day, eyes closed), and in state 4 (irregular respiration, presence of gross body movements, and, after the 14th day, eyes opened). The EEG of rats on the 9th and 10th day did not reveal behavioral state-specific patterns. The amplitudes of the EEG were low and only low frequencies occurred. Between the 10th-13th day an EEG pattern specific for state 1 containing high amplitudes developed. From the 14th day onwards spindles (frequencies from 14-18 Hz) occurred in the EEG during state 1. From the 14th day onwards, the EEG from the visual cortex during state 2 showed a regular and continually occurring 5 Hz rhythm. Bursts with 5 Hz waves were recorded from the visual cortex only intermittently during state 4. The EEG frequencies during the bursts varied between 5-7 Hz from the 17th day onwards. Computer analysis of the amplitude distributions showed a considerable increase in the power after the 10th day. The analysis of the frequency spectra indicated that the power increase occurred especially in the higher frequencies of the EEG signal. Visual and computer analysis of the EEG did not reveal systematic changes in the EEG after the 18th day when the EEG was similar to that recorded at older ages.