Assessing the benefits of health research: lessons from research into the use of antenatal corticosteroids for the prevention of neonatal respiratory distress syndrome
Assessing the benefits of health research: lessons from research into the use of antenatal corticosteroids for the prevention of neonatal respiratory distress syndrome
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DOI：
10.1016/j.socscimed.2004.06.038
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发表时间：
2005-03-01
影响因子：
5.4
通讯作者：
Buxton, M
中科院分区：
文献类型：
--
作者：
Hanney, S;Mugford, M;Buxton, M
健康研究带来的好处是否证明投入这些资源是合理的？解决这个问题不仅应该满足日益增长的问责要求，而且还可以加强对研究利用的理解，以及如何最好地组织卫生研究系统来增加效益。从基础研究到最终应用和患者受益的过程通常是复杂的。在关于研究利用的辩论中，预期早产时使用产前皮质类固醇具有很大的特点，并提供了对这些复杂性的见解。基于对先前研究利用和回报评估模型的分析，开发了一个框架，其中使用皮质类固醇的现有文献与作者开发的新材料相结合。可以被回顾和合成。从动物研究到人体试验的转变是由同一个人进行的。这些发现的一些早期临床应用与一系列进一步的试验同时进行。然而。这些发现的实施停滞不前，而不是像某些模型所预测的那样加速。最终对试验的系统评价在Cochrane协作的发展中发挥了作用，并增加了对实践的影响。各国采用了进一步的实施方法，包括临床指南。国家卫生研究院共识会议，以及联合王国境内的各种实施项目。本文展示了如何对这一系列研究和利用项目的效益进行评估。它的结论是，应用一个评估回报的模型可以帮助证明在这个领域的研究的好处，并提高我们对研究利用的理解。(C) 2004 Elsevier Ltd.版权所有。
Do the benefits from health research justify the resources devoted to it? Addressing this should not only meet increasing accountability demands, but could also enhance understanding of research utilisation and how best to organise health research systems to increase the benefits. The process from basic research to eventual application and patient benefit is usually complex. The use of antenatal corticosteroids when preterm delivery is expected has featured large in the debates about research utilisation and provides an insight into these complexities. Based on an analysis of previous modelling of research utilisation and payback assessment, a framework is developed in which the existing literature on the use of corticosteroids, combined with new material developed by the authors. can be reviewed and synthesised. The move from animal studies to human trials was undertaken by the same individual. Some early clinical application of the findings occurred concurrently with a series of further trials. Nevertheless. the implementation of these findings stalled rather than accelerated as is predicted by some models. The eventual systematic review of the trials played a part in the development of the Cochrane Collaboration and increased the impact on practice. Further implementation approaches were used in various countries, including clinical guidelines. a National Institutes of Health Consensus Conference, and various implementation projects within the UK. This paper shows how an assessment of the benefits from this stream of research and utilisation projects can be constructed. It concludes that the application of a model for assessing payback can help to demonstrate the benefits from the research in this field and enhance our understanding of research utilisation. (C) 2004 Elsevier Ltd. All rights reserved.