Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family
Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family
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DOI：
10.1016/j.biocel.2004.01.017
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发表时间：
2004-06-01
影响因子：
4
通讯作者：
Sage, EH
中科院分区：
文献类型：
--
作者：
Sullivan, MM;Sage, EH
Hevin是一种与细胞外基质相关的分泌型糖蛋白，属于酸性分泌蛋白，富含半胱氨酸(SPARC)家族的基质细胞蛋白。它包含三个保守的结构域，与细胞黏附、迁移和增殖的调节有关。Hevin在胚胎发育和组织重塑过程中表达，在大脑和血管系统中尤为明显。它在一些癌症中的下调以及SPARC对其功能补偿的可能性，导致了最近对Hevin作为肿瘤抑制因子和血管生成调节因子的兴趣。(C)2004年，爱思唯尔有限公司出版。
Hevin is an extracellular matrix-associated, secreted glycoprotein belonging to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins. It contains three conserved structural domains that are implicated in the regulation of cell adhesion, migration, and proliferation. Hevin is expressed during embryogenesis and tissue remodeling and is especially prominent in brain and vasculature. Its down-regulation in a number of cancers and the possibility of its functional compensation by SPARC has led to recent interest in hevin as a tumor suppressor and regulator of angiogenesis. (C) 2004 Published by Elsevier Ltd.