Application of the electronic nose for uremia diagnosis
Application of the electronic nose for uremia diagnosis
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DOI：
10.1016/s0925-4005(01)00625-6
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发表时间：
2001-06-01
影响因子：
8.4
通讯作者：
Hong, RI
中科院分区：
文献类型：
--
作者：
Lin, YJ;Guo, HR;Hong, RI
呼吸分析提供了一种通过检测呼吸中的特殊气味来诊断疾病的方法;其临床应用之一，电子鼻，已被证明是一种非侵入性和快速的诊断工具。在这项研究中，传感器模块的电子鼻设计了6个12 MHz AT切石英晶体阵列。采用基于结构的计算机模拟设计探针肽，模拟嗅觉受体蛋白（ORP）的三维结构与目标气体分子对接，合成探针肽。在临床试验中，该传感器模块对正常人、尿毒症患者、慢性肾功能不全（CRI）患者和慢性肾功能衰竭（CRF）患者的呼吸进行了判别分析，判别正确率为86.78%。一般来说，正常受试者可以完全与患者区分开来。(C)2001爱思唯尔科技有限公司。保留所有权利。
Breath analysis provides a way to diagnose diseases by detection of special odors in breaths; one of its clinical applications, electronic nose, has been proved as a non-invasive and rapid tool for diagnosis. In this study, a sensor module of the electronic nose is devised with six 12 MHz AT-cut quartz crystals array. probe peptides are designed with structure-based computer simulation, in which a simulated three-dimensional structure of the olfactory receptor protein (ORP) is docking with target gas molecules, and then synthesized. In the clinical test, this sensor module discriminates breaths from the normal subjects, patients with uremia, patients with chronic renal insufficiency (CRI) and patients with chronic renal failure (CRF) well by the discriminating analysis with a correct classification of 86.78%. In general, the normal subjects can be distinguished completely from the patients. (C) 2001 Elsevier Science B.V. All rights reserved.