INTRAVENOUS GAMMA-GLOBULIN IN REFRACTORY IMMUNE THROMBOCYTOPENIC PURPURA - EFFICACY WITH OR WITHOUT CONCOMITANT STEROID-THERAPY
INTRAVENOUS GAMMA-GLOBULIN IN REFRACTORY IMMUNE THROMBOCYTOPENIC PURPURA - EFFICACY WITH OR WITHOUT CONCOMITANT STEROID-THERAPY
复制标题
DOI：
10.1002/ajh.2830180111
复制
发表时间：
1985-01-01
影响因子：
12.8
通讯作者：
ANDERSON, T
中科院分区：
文献类型：
--
作者：
ABRAMS, RA;ASTER, R;ANDERSON, T
2例免疫性血小板减少性紫癜（ITP）患者接受了5天疗程的静脉注射丙种球蛋白（Gamimune‐Cutter）400 mg/kg/天治疗，这些患者对类固醇和脾切除术的常规治疗无效。即使在类固醇逐渐减量的情况下，两例病例均观察到改善。在血小板减少症随后复发或恶化的每例病例中，在不伴随类固醇的情况下进一步IV丙种球蛋白治疗，随后血小板数量明确增加。这些观察结果证实，IV丙种球蛋白的Cutter制剂可有效治疗难治性ITP，并表明在这种临床环境下，在不伴随皮质类固醇给药的情况下，可发生IV丙种球蛋白应答。
Two patients with immune thrombocytopenic purpura (ITP) refractory to conventional management with steroids and splenectomy were treated with 5‐day courses of intravenous gamma globulin (Gamimune‐Cutter), 400 mg/kg/day. Improvement was observed in both cases even while steroids were being tapered. In each case when thrombocytopenia subsequently recurred or worsened, further therapy with IV gamma globulin without concomitant steroids was followed by definite increase in platelet numbers. These observations confirm that the Cutter preparation of IV gamma globulin is efficacious in the management of refractory ITP and suggest that in this clinical setting response to IV gamma globulins can occur without concomitant administration of corticosteroids.