Effect of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma
Effect of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma
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DOI：
10.3760/cma.j.issn.1008-1275.2010.02.002
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发表时间：
2010-04-01
影响因子：
2.1
通讯作者：
Huang Wei-dong
中科院分区：
文献类型：
--
作者：
Lu Yuan-qiang;Gu Lin-hui;Huang Wei-dong
Objective: To investigate the effect and clinical significance of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma.Methods: Thirty-three patients with severe trauma were randomly divided into a control group (n=16) and a treatment group (n=17). The patients of two groups were all treated conventionally, and the only difference was that Xuebijing injection was given to patients of the treatment group. The CD4+ and CD8+ subpopulations of T-lymphocyte in the peripheral blood were detected respectively on admission, 3rd and 5th days after trauma by double antibody labeling and flow cytometry.Results: The CD4+ T-lymphocytes and CD4+/CD8+ ratio of peripheral blood in patients with severe trauma decreased markedly on the 3rd and 5th days after trauma. Furthermore, compared with control group, the peripheral CD4+ T-lymphocytes and CD4+/CD8+ ratio of treatment group renewed obviously on the 5th day after trauma, and showed statistical differences (P
