Cryptococcosis: clinical and biological aspects
Cryptococcosis: clinical and biological aspects
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DOI：
10.1080/mmy.38.s1.205.213
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发表时间：
2000-01-01
期刊：
影响因子：
2.9
通讯作者：
Levitz, SM
中科院分区：
文献类型：
--
作者：
Kwon-Chung, KJ;Sorrell, TC;Levitz, SM
20世纪80年代初至90年代初，随着获得性免疫缺陷综合征（艾滋病）流行病的出现，隐球菌病的发病率急剧上升。由于开发了更有效的抗逆转录病毒疗法和旨在预防真菌感染的预防性治疗方案，自20世纪90年代中期以来，欧洲和美国的隐球菌病发病率一直在下降。然而，这种疾病仍然被认为是免疫功能低下患者中最常见的危及生命的机会性真菌感染之一，特别是在感染人类免疫缺陷病毒（HIV）的患者中。因此，对该疾病的临床和生物学方面的研究兴趣仍然很高。除了先前开展的研究领域外，隐球菌研究界利用当前的测序技术，启动了新型隐球菌变种的基因组测序。本文综述了从病理生物学、生物化学、免疫学到基因组学等各个领域的研究兴趣。
The incidence of cryptococcosis rose dramatically with the advent of the acquired immune deficiency syndrome (AIDS) epidemic in the early 1980s until the early 1990s. The frequency of cryptococcosis has been declining since mid 1990s in Europe and America due to the development of more effective antiretroviral therapy and prophylactic treatment regimens designed to prevent fungal infections. The disease, however, is still recognized as one of the most common life-threatening opportunistic fungal infections in immunocompromised patients, particularly among those infected with human immunodeficiency virus (HIV). For this reason, research interest in clinical and biological aspects of the disease remains high. In addition to previously embarked areas of research, the cryptococcal research community has taken advantage of the current sequencing technology and initiated genome sequencing of Cryptococcus neoformans var. neoformans. This review includes various areas of research interest ranging from pathobiology, biochemistry and immunology, to genomics.