Periodic contrast-enhanced computed tomography for thermal ablation monitoring: a feasibility study.
Periodic contrast-enhanced computed tomography for thermal ablation monitoring: a feasibility study.
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DOI：
10.1109/iembs.2009.5333500
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Lee FT Jr
中科院分区：
文献类型：
--
作者：
Brace CL;Mistretta CA;Hinshaw JL;Lee FT Jr
图像引导的肿瘤消融术正在迅速获得接受，用于治疗许多肿瘤。虽然成像诊断、治疗靶向和随访持续改进，但在开发用于监测消融治疗的实用成像技术方面进展甚微。在这项研究中，我们证明了使用对比增强计算机断层扫描（CECT）监测消融区生长的可行性，时间分辨率为2分钟。高度约束反投影（HYPR）后处理应用于CECT图像的时间序列，在采集10个时间帧后将图像质量提高了4倍。这种改进限制了使消融区可视化所需的辐射和碘化造影剂的量，特别是在早期时间点。定期CECT与HYPR处理的额外研究似乎是必要的。
Image-guided tumor ablation is rapidly gaining acceptance for treating many tumors. While imaging diagnosis, treatment targeting and follow-up continue to improve, little progress has been made in developing practical imaging techniques for monitoring ablation treatments. In this study we demonstrate the feasibility of using contrast-enhanced computed tomography (CECT) to monitor ablation zone growth with 2 min temporal resolution. Highly constrained back-projection (HYPR) post-processing is applied to the time-series of CECT images, improving image quality by a factor of four after acquiring ten time frames. Such improvements limit the amount of radiation and iodinated contrast material required to visualize the ablation zone, especially at early time points. Additional study of periodic CECT with HYPR processing appears warranted.