NEGATIVE CORRELATION BETWEEN THE CHANGE IN BONE-MINERAL DENSITY AND SERUM OSTEOCALCIN IN PATIENTS WITH HYPERTHYROIDISM
NEGATIVE CORRELATION BETWEEN THE CHANGE IN BONE-MINERAL DENSITY AND SERUM OSTEOCALCIN IN PATIENTS WITH HYPERTHYROIDISM
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DOI：
10.1210/jcem-70-3-766
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发表时间：
1990-03-01
影响因子：
5.8
通讯作者：
MIN, HK
中科院分区：
文献类型：
--
作者：
LEE, MS;KIM, SY;MIN, HK
为探讨甲亢患者骨密度和成骨细胞活性的变化及其相互关系，我们测定了109例Graves病患者的骨密度和血清骨钙素，其中包括75例未经治疗的Graves病患者和34例治疗中的Graves病患者，以及200例正常对照。骨密度的变化程度用Z变换进行量化，其中我们使用我们开发的年龄和性别匹配的1：1配对过程中获得的骨密度的平均值和SD。女性甲亢患者的脊柱、股骨颈、转子和Ward's三角的骨密度较低，但男性患者的骨密度并不低。未经治疗的Graves病患者血清骨钙素升高，并与脊柱、股骨颈和转子的骨密度Z值呈负相关。总之，甲状腺功能亢进症患者成骨细胞活性指数升高，可能继发于甲状腺功能亢进引起的骨吸收增加，导致骨密度降低。通过使用年龄和性别匹配配对过程中获得的参数来量化骨密度的变化似乎是一种有效的统计分析方法。
To assess the changes in bone mineral density and osteoblastic activity in patients with hyperthyrodism and to investigate the relationship between those changes, we measured bone mineral density and serum osteocalcin in 109 patients with Graves'' disease, comprising 75 untreated patients and 34 patients under treatment, and 200 normal controls. The degree of change in bone mineral density was quantified with Z transformation, in which we used means and SDs of bone mineral densities obtained in the process of age- and sex-matched 1:1 pairing developed by ourselves. Bone mineral density was low in female patients with hyperthyroidism in the spine, femur neck, trochanter, and Ward''s triangle, but was not low in male patients. Serum osteocalcin was elevated in patients with untreated Graves'' disease and correlated negatively with the Z values of bone mineral densities of the spine, femur neck, and trochanter. In conclusion, indices of osteoblastic activity were elevated in patients with hyperthyroidism, probably secondary to a thyroid hormone-induced increase in bone resorption which resulted in reduced bone mineral density. Quantification of the change in bone mineral density by using the parameters derived in the process of age- and sex-matched pairing seems to be an efficient method for statistical analyses.