Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis
Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis
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DOI：
10.1111/j.1365-2249.2007.03539.x
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发表时间：
2008-01-01
影响因子：
4.6
通讯作者：
Kim, J. -K.
中科院分区：
文献类型：
--
作者：
Kwon, H. -S.;Oh, S. -M.;Kim, J. -K.
炎症性肠病（IBD）的特征在于肠道中有害的免疫反应性以及促炎和抗炎反应性之间的失衡。本研究的目的是确定口服glabridin（glabridin的功能成分）是否可以改善葡聚糖硫酸钠（DSS）诱导的结肠炎，以及了解可能的潜在机制。通过用5%DSS处理7天在BALB/c小鼠中诱导急性实验性结肠炎。光甘草定（10或50 mg/kg/天）给药7天。光甘草定治疗显著降低死亡率、体重减轻、结肠缩短和严重临床症状。这与结肠结构破坏的显著改善、结肠髓过氧化物酶（MPO）活性的显著降低以及炎症介质（如一氧化氮（NO）、前列腺素（PG）E-2和促炎细胞因子）的产生有关。这些结果表明，光甘草定介导的结肠直肠部位的抗炎作用可能是一个有用的治疗IBD的方法。
Inflammatory bowel disease (IBD) is characterized by detrimental immune reactivity in the gut, and the imbalance between proinflammatory and anti-inflammatory reactivity. The aims of this study were to determine whether oral administration of glabridin, a functional component of liquorice, could ameliorate dextran sulphate sodium (DSS)-induced colitis, as well as to understand the possible underlying mechanisms. Acute experimental colitis was induced in BALB/c mice by treatment with 5% DSS for 7 days. Glabridin (10 or 50 mg/kg/day) was given for 7 days. Treatment with glabridin significantly attenuated mortality, loss of body weight, shortening of the colon and severe clinical symptoms. This was associated with a remarkable amelioration of the disruption of the colonic architecture, a significant reduction in colonic myeloperoxidase (MPO) activity and the production of inflammatory mediators such as nitric oxide (NO), prostaglandin (PG) E-2, and proinflammatory cytokines. These results suggest that glabridin-mediated anti-inflammatory action on colorectal sites may be a useful therapeutic approach to IBD.