The role of lysosomes and proteases in hormone secretion and degradation.
The role of lysosomes and proteases in hormone secretion and degradation.
复制标题
溶酶体和蛋白酶在激素分泌和降解中的作用。
DOI：
10.1210/edrv-2-2-137
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发表时间：
1981
影响因子：
20.3
通讯作者：
B. S. Chertow
中科院分区：
文献类型：
--
作者：
B. S. Chertow
在内分泌细胞中，溶酶体与激素分泌之间存在着复杂的关系。这些关系可能从一个共同的进化起源发展而来。随着溶酶体和分泌系统的进化，它们之间发展了多种功能关系。从基本的细胞内“消化”作用，溶酶体及其蛋白水解酶在激素加工、释放和细胞内外降解中发展出新的和不同的起源和功能。1.1蛋白水解酶和激素可得性激素效应是激素在靶受体上可得性的函数。蛋白水解酶在调节激素的可用性方面具有重要作用：1)增加细胞内前体分泌形式的产生，2)促进释放或胞外分泌，3)通过降解过量的细胞内激素来降低细胞内浓度，4)血清中蛋白水解酶使激素失活或激活，5)在靶细胞中降解激素。
In endocrine cells, complex relationships exist between the lysosome and hormone secretion. These relationships may have developed from a common evolutionary origin. As lysosomal and secretory systems evolved, diverse functional relationships developed between them. From a basic intracellular “digestive” role, lysosomes and their proteolytic enzymes developed new and varied origins and functions in hormone processing, release, and intraand extracellular degradation. 1.1 Proteolytic enzymes and hormone availability Hormone effects are a function of the availability of hormone at target receptors. Proteolytic enzymes can have an important role in regulating the availability of hormone by: 1) increasing the intracellular production of secreted forms from precursors, 2) facilitating release or exocytosis, 3) decreasing intracellular concentrations by degradation of excessive intracellular hormone, 4) inactivation or activation of hormone by proteolytic enzymes in serum, and 5) degradation of hormone in target...