Mitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyte.
Mitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyte.
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DOI：
10.1586/erc.09.48
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发表时间：
2009-08
影响因子：
2
通讯作者：
Sussman MA
中科院分区：
文献类型：
--
作者：
Sussman MA
线粒体作为细胞存活介质的中心作用是无可争议的，并且作为减轻心肌病损伤后凋亡性细胞死亡的干预策略的焦点越来越受到关注。信号转导研究的遗产已经证明，线粒体的完整性可以通过参与细胞存活的激酶来增强。在许多正在研究的生存信号级联中，Akt对线粒体生物学的广泛影响是众所周知的。然而，尽管多年的研究，新兴的研究继续揭示新的机制，在心肌细胞线粒体的背景下，Akt信号的保护作用。本文综述了两个新出现的途径，介导的保护线粒体功能下游的Akt：己糖激酶和Pim-1激酶。
The central role of mitochondria as mediators of cell survival is indisputable and gathering increasing attention as a focal point for interventional strategies to mitigate apoptotic cell death in the wake of cardiomyopathic injury. A legacy of signal transduction studies has proven that mitochondrial integrity can be enhanced by kinases involved in cell survival. Among the many survival signaling cascades under investigation, the wide-ranging impact of Akt upon mitochondrial biology is well known. However, despite years of investigation, emerging research continues to reveal new mechanisms governing the protective effects of Akt signaling in the context of cardiomyocyte mitochondria. This review focuses on two emerging pathways that mediate preservation of mitochondrial function downstream of Akt: hexokinase and Pim-1 kinase.