Association between high-density lipoprotein cholesterol and all-cause mortality in the general population of northern China
Association between high-density lipoprotein cholesterol and all-cause mortality in the general population of northern China
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DOI：
10.1038/s41598-019-50924-4
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发表时间：
2019-10-08
影响因子：
4.6
通讯作者：
Sun, Jianhui
中科院分区：
文献类型：
--
作者：
Li, Xintao;Guan, Bo;Sun, Jianhui
最近的研究对非常高水平的高密度脂蛋白胆固醇（HDL-c）的良好预后提出了合理的怀疑。我们的目的是利用2006年至2015年中国北方一项观察性队列研究的数据，调查HDL-c水平与全因死亡率之间的关系。根据HDL-c水平（mg/dl = 80）将研究人群分为六组。Cox风险回归模型用于估计HDL-c水平与全因死亡率之间的关系。本次分析共纳入100,070名参与者（年龄51.9±12.7岁）。在平均8.76年的随访期间，确定了7,362例死亡（死亡率为每1000人年8.40例）。年龄与HDL-c水平之间存在显著交互作用（交互作用P < 0.001）。在65岁及以上的人群中，HDL-c水平与总死亡率之间没有明显的关联。相比之下，年轻参与者（= 80 mg/dl）的HDL-c水平与全因死亡率呈u型关系，与参考水平（60至69 mg/dl）相比，HDL-c水平与总死亡率风险增加独立相关。这些发现表明，非常高的HDL-c水平可能不代表良好的预后，特别是在年轻人中。
Recent studies proposed reasonable doubts about the good prognosis of very high levels of high-density lipoprotein cholesterol (HDL-c). We aimed to investigate the association between HDL-c levels and all-cause mortality using data from an observational cohort study in northern China from 2006 to 2015. The study population was stratified into six groups by HDL-c levels in mg/dl (= 80). Cox hazards regression models were used to estimate the association between HDL-c levels and all-cause mortality. In total, 100,070 participants (aged 51.9 +/- 12.7 years) were included in the current analysis. During a mean follow-up of 8.76 years, 7,362 deaths were identified (mortality rate, 8.40 per 1000 person-years). There was a significant interaction effect between age and HDL-c levels (P for interaction < 0.001). Among individuals aged 65 and older, no significant association was found between HDL-c levels and total mortality. In contrast, HDL-c levels showed a U-shaped relationship with all-cause mortality in younger participants (= 80 mg/dl) were independently associated with increased total mortality risk compared with the reference level (60 to 69 mg/dl). These findings suggest that very high HDL-c levels may not represent a good prognosis, especially in younger individuals.