Seven terminal steps in a biosynthetic pathway leading from DNA to transfer RNA
Seven terminal steps in a biosynthetic pathway leading from DNA to transfer RNA
复制标题
从 DNA 到转移 RNA 的生物合成途径的七个最终步骤
DOI：
10.1021/ar50119a006
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发表时间：
1977
影响因子：
18.3
通讯作者：
W. McClain
中科院分区：
文献类型：
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作者：
W. McClain
科学的大部分工作都采取路径阐明的形式。随着探测工具的出现，它们揭示了被调查对象的更细微和更细微的细节。在随附的一篇文章中，Alexander Rich追踪了酵母苯丙氨酸转移RNA(TRNAphe)中多核苷酸链的主干，揭示了一个非常详细的架构。1生物体产生数十种不同的tRNA，每一种都精确地规定了核苷酸序列和链长。核苷酸序列由DNA决定，但链的长度由一系列复杂的步骤决定，这些步骤形成
Much of the work of science takes the form of pathway elucidation. As the tools of exploration be-come sharper, they reveal infiner and finer detail the object under investigation. In an accompanying article, Alexander Rich traces the backbone of the poly-nucleotide chain in yeast phenylalanine transfer RNA (tRNAphe), revealing a fantastically detailed architec-ture. 1 Living organisms manufacture dozens of dif-ferent tRNAs, each to precisespecifications of nu-cleotide sequence andchain length. The nucleotide sequence is determined by the DNA, but the chain length is specified by a complex series of steps that form