The LEAD (Lung, Heart, Social, Body) Study: Objectives, Methodology, and External Validity of the Population-Based Cohort Study
The LEAD (Lung, Heart, Social, Body) Study: Objectives, Methodology, and External Validity of the Population-Based Cohort Study
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DOI：
10.2188/jea.je20180039
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发表时间：
2019-08-01
影响因子：
4.7
通讯作者：
Breyer, Marie-Kathrin
中科院分区：
文献类型：
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作者：
Breyer-Kohansal, Robab;Hartl, Sylvia;Breyer, Marie-Kathrin
背景：肺、心、社会、身体（LEAD）研究（ClinicalTrials.gov; NCT01727518; http://clinicaltrials.gov）是一项纵向、观察性、基于人群的奥地利队列研究，旨在研究影响呼吸系统健康和生命合并症的遗传、环境、社会、发育和衰老因素之间的关系。铅的一般工作假设是，这些遗传、环境和社会经济因素的相互作用影响肺部发育和衰老，几种非传染性疾病（呼吸、心血管、代谢和神经）的发生风险，以及它们的表型（即临床）表现。方法：铅随机抽取2011-2016年维也纳居民（城市队列）和下奥地利6个村庄（农村队列）的所有居民（按年龄、性别、居住地分层）。参与者将每四年随访一次。在研究的四个领域（肺、心、社会、身体）都进行了大量的调查和测量，包括筛查肺部、心血管和代谢疾病、骨质疏松症和认知功能的数据。血液和尿液样本被储存在生物库中，以备将来的调查。结果：共纳入11.423例男性（47.6%）和女性（52.4%），年龄6 ~ 80岁。与政府统计数据相比，铅在年龄、性别、公民身份和吸烟状况方面的外部效度较高。结论：总之，LEAD队列的建立遵循了高质量标准；它是奥地利人口的代表，并提供了一个平台，了解肺部发育和衰老是成年早期和晚期人类健康的关键机制。
Background: The Lung, hEart, sociAl, boDy (LEAD) Study (ClinicalTrials.gov; NCT01727518; http://clinicaltrials.gov) is a longitudinal, observational, population-based Austrian cohort that aims to investigate the relationship between genetic, environmental, social, developmental and ageing factors influencing respiratory health and comorbidities through life. The general working hypothesis of LEAD is the interaction of these genetic, environmental and socioeconomic factors influences lung development and ageing, the risk of occurrence of several non-communicable diseases (respiratory, cardiovascular, metabolic and neurologic), as well as their phenotypic (ie, clinical) presentation.Methods: LEAD invited from 2011-2016 a random sample (stratified by age, gender, residential area) of Vienna inhabitants (urban cohort) and all the inhabitants of six villages from Lower Austria (rural cohort). Participants will be followed-up every four years. A number of investigations and measurements were obtained in each of the four domains of the study (Lung, hEart, sociAl, boDy) including data to screen for lung, cardiovascular and metabolic diseases, osteoporosis, and cognitive function. Blood and urine samples are stored in a biobank for future investigations.Results: A total of 11.423 males (47.6%) and females (52.4%), aged 6-80 years have been included in the cohort. Compared to governmental statistics, the external validity of LEAD with respect to age, gender, citizenship, and smoking status was high.Conclusions: In conclusion, the LEAD cohort has been established following high quality standards; it is representative of the Austrian population and offers a platform to understand lung development and ageing as a key mechanism of human health both in early and late adulthood.