Circulating miRNA signature for early diagnosis of lung cancer.
Circulating miRNA signature for early diagnosis of lung cancer.
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DOI：
10.1002/emmm.201100155
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发表时间：
2011-08
影响因子：
11.1
通讯作者：
Yang, Pan-Chyr
中科院分区：
文献类型：
--
作者：
Lin, Pei-Ying;Yang, Pan-Chyr
非小细胞肺癌（NSCLC）是世界范围内癌症死亡的主要原因。尽管最近对NSCLC基因组学、疾病分子机制和靶向治疗的发展进行了大量研究，在一定程度上改善了治疗反应，但总体5年生存率仅为10- 15%左右。长期以来，5年生存率如此之低的主要原因是四分之三的患者诊断晚，导致疾病晚期和无法手术。几十年来，肺癌研究一直试图开发允许早期诊断的筛查模式。然而，与过去10年在预后和预测性生物标志物研究方面取得的成功相比，早期肺癌筛查的进展仍然有限，仅限于影像学研究，20世纪70年代的胸部X线摄影和痰细胞学筛查计划未能降低癌症死亡率。21世纪初进行的低剂量螺旋胸部计算机断层扫描（LDCT）筛查试验通常导致早期肺癌诊断数量的显着增加，但晚期癌症的发展或癌症死亡率没有明显降低
Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. Despite the numerous recent studies on NSCLC genomics, molecular mechanisms of disease and the development of targeted therapies, which improve treatment responses to a certain extent, the overall 5-year survival rate is only around 10–15%. The main reason for such a low 5-year survival rate has long been attributed to late diagnosis of the disease in three quarters of patients, resulting in advanced and inoperable diseases. Lung cancer studies for decades have attempted to develop screening modalities that allow early diagnosis. However, in contrast to the success in prognostic and predictive biomarker research during the past 10 years, the progress in early lung cancer screening is still limited and restricted to imaging studies.Chest radiography and sputum cytology screening programs in the 1970s had failed to reduce cancer mortality. Lowdose spiral chest computed tomography (LDCT) screening trials carried out in the 2000s generally resulted in a significant increase in the number of early-stage lung cancer diagnoses, but without apparent reduction in development of advanced cancers or cancer mortality
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影响因子：
8.8
作者：
通讯作者：
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DOI：
10.1073/pnas.0804549105
发表时间：
2008-07-29
影响因子：
11.1
作者：
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通讯作者：
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DOI：
10.1073/pnas.1100048108
发表时间：
2011-03-01
影响因子：
11.1
作者：
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通讯作者：
Sozzi, Gabriella
影响因子：
51.1
作者：
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通讯作者：
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