Bronchopulmonary dysplasia and neurobehavioural outcomes at birth and 2 years in infants born before 30 weeks
Bronchopulmonary dysplasia and neurobehavioural outcomes at birth and 2 years in infants born before 30 weeks
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DOI：
10.1136/archdischild-2021-323405
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发表时间：
2022-08-23
影响因子：
4.4
通讯作者：
Lester, Barry M.
中科院分区：
文献类型：
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作者：
Martin, Monika;Smith, Lynne;Lester, Barry M.
在一项针对出生年龄< 30周的婴儿的前瞻性多中心研究中，BPD严重程度与NNNS测量的出院时的神经行为结局和2年结局相关。目的探讨支气管肺发育不良（BPD）早产儿出院前的神经行为风险。设计与患者：676例妊娠30周前出生的新生儿的纵向研究。设6所大学附属9所大学新生儿重症监护室。所有人都是佛蒙特牛津网络（VON）的参与者。2014年4月至2016年6月，新生儿神经行为和预后研究纳入了新生儿神经行为和预后研究。前瞻性病历回顾、VON定义和标准以及孕产妇访谈用于收集孕产妇和新生儿医学变量和社会环境数据。出院时新生儿重症监护病房网络神经行为量表（NNNS）；Bayley婴幼儿发展量表第三版（Bayley- iii）和矫正年龄2岁大肌肉运动功能分类系统。结果中重度BPD患儿注意力不集中（Wald chi(2) 9.68, p=0.008），嗜睡（Wald chi(2) 9.91, p=0.007），非最佳反射增加（Wald chi(2) 7.37, p=0.025）。患有中度/重度BPD的婴儿更有可能获得Bayley-III语言和运动评分
In a prospective, multicenter study of infants < 30 weeks GA, BPD severity was associated with neurobehavioral outcomes at the time of hospital discharge as measured by NNNS, and with 2 year outcomes.Objective To identify neurobehavioural risks in preterm infants with bronchopulmonary dysplasia (BPD) prior to hospital discharge. Design and patients Longitudinal study of 676 newborns born before 30 weeks of gestation. Setting Nine university NICUs affiliated with six universities. All were Vermont Oxford Network (VON) participants. Patients and interventions Infants were enrolled in the Neonatal Neurobehavior and Outcomes in Very Preterm Infants Study from April 2014 to June 2016. Prospective medical record reviews, VON definitions and criteria, and maternal interviews were used to collect maternal and neonatal medical variables and socioenvironmental data. Main Outcome Measures NICU Network Neurobehavioral Scale (NNNS) at the time of hospital discharge; Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) and Gross Motor Function Classification System at 2 years' corrected age. Results Infants with moderate/severe BPD were less attentive (Wald chi(2) 9.68, p=0.008), more lethargic (Wald chi(2) 9.91, p=0.007), with increased non-optimal reflexes (Wald chi(2) 7.37, p=0.025). Infants with moderate/severe BPD were more likely to have Bayley-III language and motor scores