Evidence for the synthesis of lung surfactant dipalmitoyl phosphatidylcholine by a "remodeling" mechanism.
Evidence for the synthesis of lung surfactant dipalmitoyl phosphatidylcholine by a "remodeling" mechanism.
复制标题
通过“重塑”机制合成肺表面活性剂二棕榈酰磷脂酰胆碱的证据。
DOI：
10.1016/s0006-291x(80)80181-1
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发表时间：
1980
影响因子：
3.1
通讯作者：
W. Longmore
中科院分区：
文献类型：
--
作者：
M. Engle;R. Sanders;W. Longmore
Synthesis of dipalmitoyl phosphatidylcholine in the isolated perfused rat lung has been studied using radio labeled glucose and palmitate. Following subsequent isolation of lamellar bodies, microsomes and surfactant and nonsurfactant fractions, evidence in support of at least two pools of palmitate, one synthesizedde novofrom glucose and one supplied by exogenous palmitate for dipalmitoyl phosphatidylcholine synthesis has been obtained. Further, the results indicate that palmitate of dipalmitoyl phosphatidylcholine is derived to a greater extent from thede novosynthesized pool of palmitate than from exogenous palmitate and that dipalmitoyl phosphatidylcholine synthesis involves a “remodeling” mechanism.
